Multifunctional trackable dendritic scaffolds and delivery agents

Roey J. Amir, Lorenzo Albertazzi, Jenny Willis, Anzar Khan, Taegon Kang, Craig J. Hawker

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Dual action: Trackable multifunctional dendritic scaffolds with high internal loading capacity were synthesized based on a PEG core. Orthogonal functionalization of chain-end and internal groups allowed the dendrimers to be both labeled and loaded with releasable dyes for simultaneous monitoring of the dendritic carrier and release of the dye payload inside living cells (see picture).

Original languageEnglish
Pages (from-to)3425-3429
Number of pages5
JournalAngewandte Chemie - International Edition
Volume50
Issue number15
DOIs
Publication statusPublished - 2011 Apr 4
Externally publishedYes

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Keywords

  • click chemistry
  • delivery platforms
  • dendrimers
  • dye tracking
  • fluorescence microscopy

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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