Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus

Jae Yeon Kim, Hwanbum Lee, Keun Sang Oh, Seho Kweon, Ok cheol Jeon, Youngro Byun, Kwang Meyung Kim, Ick Chan Kwon, Sang Yoon Kim, Soon Hong Yuk

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The invitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using invivo animal models. Invitro-. invivo correlation was discussed in relation to manipulation of the NP structures.

Original languageEnglish
Pages (from-to)8444-8449
Number of pages6
JournalBiomaterials
Volume34
Issue number33
DOIs
Publication statusPublished - 2013 Nov 1
Externally publishedYes

Keywords

  • Core/shell nanoparticles
  • Layer-by-layer approach
  • Lipid bilayers
  • Pluronics
  • Sustained delivery of exenatide

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics

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    Kim, J. Y., Lee, H., Oh, K. S., Kweon, S., Jeon, O. C., Byun, Y., Kim, K. M., Kwon, I. C., Kim, S. Y., & Yuk, S. H. (2013). Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus. Biomaterials, 34(33), 8444-8449. https://doi.org/10.1016/j.biomaterials.2013.07.040