Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus

Jae Yeon Kim, Hwanbum Lee, Keun Sang Oh, Seho Kweon, Ok cheol Jeon, Youngro Byun, Kwangmeyung Kim, Ick Chan Kwon, Sang Yoon Kim, Soon Hong Yuk

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The invitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using invivo animal models. Invitro-. invivo correlation was discussed in relation to manipulation of the NP structures.

Original languageEnglish
Pages (from-to)8444-8449
Number of pages6
JournalBiomaterials
Volume34
Issue number33
DOIs
Publication statusPublished - 2013 Nov

Keywords

  • Core/shell nanoparticles
  • Layer-by-layer approach
  • Lipid bilayers
  • Pluronics
  • Sustained delivery of exenatide

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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