Multimodal evaluation of xenograft tumors in mice with an in-vivo stereo imaging system and small-animal PET/CT

Onseok Lee, Gunwoo Lee, Mingi Kim, Seok Ki Kim, Yoosang Baek, Chil Hwan Oh

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    In small-animal studies, calipers are the standard method used for measurement of external tumor size. However, as tumors are not usually prolate spheroids, this may lead to inaccuracies in the data. Also, correlations vary according to the kind and size of tumors. Tumors were generated by transplanting B16 mouse melanoma cells into the back of Balb/c nude mice. True volumes were measured by calipers, an in-vivo stereo imaging system, and as a standard uptake value (SUV) by 18F-fluorodeoxyglucose ([18F]FDG)-PET. Correlations between measurements were analyzed. Correlation with the true volume was higher for measurements using the in-vivo stereo imaging system (r = 0.876) than with calipers (r= 0.744). Measurement of melanoma volume has a larger measuring error when performed using a caliper compared with measurements performed by stereo imaging when the volume of the melanoma is small. Correlation of the volume and PET-SUV by a caliper is low as the size of the melanoma increases. This same relationship exists with the comparison of stereo imaging and PET-SUV. The correlation between the SUV of [18F]FDG-PET and tumor volume with the melanoma is expected to be important in related future studies.

    Original languageEnglish
    Pages (from-to)349-359
    Number of pages11
    JournalMelanoma Research
    Volume23
    Issue number5
    DOIs
    Publication statusPublished - 2013 Jan 1

    Keywords

    • Caliper
    • Correlation
    • Standard uptake value
    • Stereo image
    • Tumor volume

    ASJC Scopus subject areas

    • Oncology
    • Dermatology
    • Cancer Research

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