TY - JOUR
T1 - Multimodal label-free detection and discrimination for small molecules using a nanoporous resonator
AU - Park, Jinsung
AU - Bang, Doyeon
AU - Jang, Kuewhan
AU - Kim, Eunkyoung
AU - Haam, Seungjoo
AU - Na, Sungsoo
N1 - Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) under grant nos NRF-2013-044213, ERC-2007-0056094 and NRF-2013058102, which is funded by the Ministry of Science, ICT & Future Planning. Further, this work was supported by BioNano Health-Guard Research Center funded by the Ministry of Science, ICT & Future Planning (MSIP) of Korea as Global Frontier Project (grant no. H-GUARD_2013M3A6B2078946).
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/3/28
Y1 - 2014/3/28
N2 - To detect chemical or biological threats, it is crucial that sensor devices can differentiate various target molecules. In general, each different sensing method has its own strengths and weaknesses due to their respective limitations. For example, although resonant sensors have high sensitivity, they are not able to discriminate target molecules. At the same time, although surface-enhanced Raman spectroscopy is a representative label-free detection method that can discriminate target molecules, its fabrication is often complex and expensive. Here we present a label-free multimodal nanoporous resonator-based system for small molecule detection and discrimination that combines the strengths of each of these sensing methods. Our approach is not only able to improve the sensitivity of the resonant sensor but it can also discriminate the target molecules. Furthermore, the fabrication process is swift (lasting <3ǎ €‰min) and convenient.
AB - To detect chemical or biological threats, it is crucial that sensor devices can differentiate various target molecules. In general, each different sensing method has its own strengths and weaknesses due to their respective limitations. For example, although resonant sensors have high sensitivity, they are not able to discriminate target molecules. At the same time, although surface-enhanced Raman spectroscopy is a representative label-free detection method that can discriminate target molecules, its fabrication is often complex and expensive. Here we present a label-free multimodal nanoporous resonator-based system for small molecule detection and discrimination that combines the strengths of each of these sensing methods. Our approach is not only able to improve the sensitivity of the resonant sensor but it can also discriminate the target molecules. Furthermore, the fabrication process is swift (lasting <3ǎ €‰min) and convenient.
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U2 - 10.1038/ncomms4456
DO - 10.1038/ncomms4456
M3 - Article
C2 - 24675143
AN - SCOPUS:84897407375
VL - 5
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 3456
ER -