Abstract
To detect chemical or biological threats, it is crucial that sensor devices can differentiate various target molecules. In general, each different sensing method has its own strengths and weaknesses due to their respective limitations. For example, although resonant sensors have high sensitivity, they are not able to discriminate target molecules. At the same time, although surface-enhanced Raman spectroscopy is a representative label-free detection method that can discriminate target molecules, its fabrication is often complex and expensive. Here we present a label-free multimodal nanoporous resonator-based system for small molecule detection and discrimination that combines the strengths of each of these sensing methods. Our approach is not only able to improve the sensitivity of the resonant sensor but it can also discriminate the target molecules. Furthermore, the fabrication process is swift (lasting <3ǎ €‰min) and convenient.
| Original language | English |
|---|---|
| Article number | 3456 |
| Journal | Nature Communications |
| Volume | 5 |
| DOIs | |
| Publication status | Published - 2014 Mar 28 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Chemistry(all)
- Physics and Astronomy(all)
Cite this
Multimodal label-free detection and discrimination for small molecules using a nanoporous resonator. / Park, Jinsung; Bang, Doyeon; Jang, Kuewhan; Kim, Eunkyoung; Haam, Seungjoo; Na, Sung Soo.
In: Nature Communications, Vol. 5, 3456, 28.03.2014.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Multimodal label-free detection and discrimination for small molecules using a nanoporous resonator
AU - Park, Jinsung
AU - Bang, Doyeon
AU - Jang, Kuewhan
AU - Kim, Eunkyoung
AU - Haam, Seungjoo
AU - Na, Sung Soo
PY - 2014/3/28
Y1 - 2014/3/28
N2 - To detect chemical or biological threats, it is crucial that sensor devices can differentiate various target molecules. In general, each different sensing method has its own strengths and weaknesses due to their respective limitations. For example, although resonant sensors have high sensitivity, they are not able to discriminate target molecules. At the same time, although surface-enhanced Raman spectroscopy is a representative label-free detection method that can discriminate target molecules, its fabrication is often complex and expensive. Here we present a label-free multimodal nanoporous resonator-based system for small molecule detection and discrimination that combines the strengths of each of these sensing methods. Our approach is not only able to improve the sensitivity of the resonant sensor but it can also discriminate the target molecules. Furthermore, the fabrication process is swift (lasting <3ǎ €‰min) and convenient.
AB - To detect chemical or biological threats, it is crucial that sensor devices can differentiate various target molecules. In general, each different sensing method has its own strengths and weaknesses due to their respective limitations. For example, although resonant sensors have high sensitivity, they are not able to discriminate target molecules. At the same time, although surface-enhanced Raman spectroscopy is a representative label-free detection method that can discriminate target molecules, its fabrication is often complex and expensive. Here we present a label-free multimodal nanoporous resonator-based system for small molecule detection and discrimination that combines the strengths of each of these sensing methods. Our approach is not only able to improve the sensitivity of the resonant sensor but it can also discriminate the target molecules. Furthermore, the fabrication process is swift (lasting <3ǎ €‰min) and convenient.
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U2 - 10.1038/ncomms4456
DO - 10.1038/ncomms4456
M3 - Article
C2 - 24675143
AN - SCOPUS:84897407375
VL - 5
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 3456
ER -