Multiparametric MR imaging of age-related changes in healthy thigh muscles

Min A. Yoon, Suk-Joo Hong, Min Cheol Ku, Chang Ho Kang, Kyung Sik Ahn, Baek Hyun Kim

Research output: Contribution to journalArticle

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Abstract

Purpose: To use multiparametric magnetic resonance (MR) imaging to assess for and establish age-related differences in healthy thigh muscles. Materials and Methods: Ninety-five subjects (47 men, 48 women; median age, 47 years) with healthy body mass index were grouped according to age: 30-39 years (n = 25), 40-49 years (n = 25), 50-59 years (n = 25), and 60-69 years (n = 20). Multiparametric MR imaging (intravoxel incoherent motion diffusionweighted, diffusion-Tensor, multiecho Dixon, and dynamic contrast material-enhanced MR imaging) was performed at 3.0 T. Two radiologists independently evaluated parametric maps of the anterior, medial, and posterior compartments. Welch-modified one-way analysis of variance and post hoc Dunnet T3 test were used to evaluate differences in apparent diffusion, true diffusion, and pseudodiffusion coefficients; perfusion fraction; fractional anisotropy (FA); fat percentage; volume transfer constant; constant efflux rate from the extravascular-extracellular space to plasma; volume fraction of the extravascular-extracellular space (Ve); incremental area under the curve; and Pearson and Spearman correlation coefficients were used to evaluate relationship strength. Multiple regression analysis was performed to identify independent predictors of age, and interrater reliability was assessed with intraclass correlation coefficients. Results: There were significant differences among the age groups in apparent diffusion coefficients (P = .010), true diffusion coefficients (P = .045), FA (P < .001), Ve (P = .029) of the anterior compartment muscles, and fat percentages of all three compartments (P < .001). Moreover, FA (Pearson r = 0.428, Spearman r = 0.431; P < .001) and Ve (r = 0.226, P = .030 and r = 0.309, P = .003) in the anterior compartment and fat percentages in all three compartments (r = 0.481, 0.475, and 0.573; r = 0.515, 0.487, and 0.667; respectively; P < .001) were positively associated with age. Multiple regression analysis showed that age was predictive of fat percentage in the posterior compartment (β = 0.500, P < .001) and of FA in the anterior compartment (β = 0.194, P = .042). Interrater reliability was excellent (intraclass correlation coefficient, 0.745-0.992). Conclusion: Multiple MR imaging parameters were significantly associated with age in thigh muscles.

Original languageEnglish
Pages (from-to)235-246
Number of pages12
JournalRadiology
Volume287
Issue number1
DOIs
Publication statusPublished - 2018 Apr 1

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Thigh
Anisotropy
Magnetic Resonance Imaging
Muscles
Fats
Extracellular Space
Regression Analysis
Contrast Media
Area Under Curve
Analysis of Variance
Body Mass Index
Age Groups
Perfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Multiparametric MR imaging of age-related changes in healthy thigh muscles. / Yoon, Min A.; Hong, Suk-Joo; Ku, Min Cheol; Kang, Chang Ho; Ahn, Kyung Sik; Kim, Baek Hyun.

In: Radiology, Vol. 287, No. 1, 01.04.2018, p. 235-246.

Research output: Contribution to journalArticle

Yoon, Min A. ; Hong, Suk-Joo ; Ku, Min Cheol ; Kang, Chang Ho ; Ahn, Kyung Sik ; Kim, Baek Hyun. / Multiparametric MR imaging of age-related changes in healthy thigh muscles. In: Radiology. 2018 ; Vol. 287, No. 1. pp. 235-246.
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abstract = "Purpose: To use multiparametric magnetic resonance (MR) imaging to assess for and establish age-related differences in healthy thigh muscles. Materials and Methods: Ninety-five subjects (47 men, 48 women; median age, 47 years) with healthy body mass index were grouped according to age: 30-39 years (n = 25), 40-49 years (n = 25), 50-59 years (n = 25), and 60-69 years (n = 20). Multiparametric MR imaging (intravoxel incoherent motion diffusionweighted, diffusion-Tensor, multiecho Dixon, and dynamic contrast material-enhanced MR imaging) was performed at 3.0 T. Two radiologists independently evaluated parametric maps of the anterior, medial, and posterior compartments. Welch-modified one-way analysis of variance and post hoc Dunnet T3 test were used to evaluate differences in apparent diffusion, true diffusion, and pseudodiffusion coefficients; perfusion fraction; fractional anisotropy (FA); fat percentage; volume transfer constant; constant efflux rate from the extravascular-extracellular space to plasma; volume fraction of the extravascular-extracellular space (Ve); incremental area under the curve; and Pearson and Spearman correlation coefficients were used to evaluate relationship strength. Multiple regression analysis was performed to identify independent predictors of age, and interrater reliability was assessed with intraclass correlation coefficients. Results: There were significant differences among the age groups in apparent diffusion coefficients (P = .010), true diffusion coefficients (P = .045), FA (P < .001), Ve (P = .029) of the anterior compartment muscles, and fat percentages of all three compartments (P < .001). Moreover, FA (Pearson r = 0.428, Spearman r = 0.431; P < .001) and Ve (r = 0.226, P = .030 and r = 0.309, P = .003) in the anterior compartment and fat percentages in all three compartments (r = 0.481, 0.475, and 0.573; r = 0.515, 0.487, and 0.667; respectively; P < .001) were positively associated with age. Multiple regression analysis showed that age was predictive of fat percentage in the posterior compartment (β = 0.500, P < .001) and of FA in the anterior compartment (β = 0.194, P = .042). Interrater reliability was excellent (intraclass correlation coefficient, 0.745-0.992). Conclusion: Multiple MR imaging parameters were significantly associated with age in thigh muscles.",
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T1 - Multiparametric MR imaging of age-related changes in healthy thigh muscles

AU - Yoon, Min A.

AU - Hong, Suk-Joo

AU - Ku, Min Cheol

AU - Kang, Chang Ho

AU - Ahn, Kyung Sik

AU - Kim, Baek Hyun

PY - 2018/4/1

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N2 - Purpose: To use multiparametric magnetic resonance (MR) imaging to assess for and establish age-related differences in healthy thigh muscles. Materials and Methods: Ninety-five subjects (47 men, 48 women; median age, 47 years) with healthy body mass index were grouped according to age: 30-39 years (n = 25), 40-49 years (n = 25), 50-59 years (n = 25), and 60-69 years (n = 20). Multiparametric MR imaging (intravoxel incoherent motion diffusionweighted, diffusion-Tensor, multiecho Dixon, and dynamic contrast material-enhanced MR imaging) was performed at 3.0 T. Two radiologists independently evaluated parametric maps of the anterior, medial, and posterior compartments. Welch-modified one-way analysis of variance and post hoc Dunnet T3 test were used to evaluate differences in apparent diffusion, true diffusion, and pseudodiffusion coefficients; perfusion fraction; fractional anisotropy (FA); fat percentage; volume transfer constant; constant efflux rate from the extravascular-extracellular space to plasma; volume fraction of the extravascular-extracellular space (Ve); incremental area under the curve; and Pearson and Spearman correlation coefficients were used to evaluate relationship strength. Multiple regression analysis was performed to identify independent predictors of age, and interrater reliability was assessed with intraclass correlation coefficients. Results: There were significant differences among the age groups in apparent diffusion coefficients (P = .010), true diffusion coefficients (P = .045), FA (P < .001), Ve (P = .029) of the anterior compartment muscles, and fat percentages of all three compartments (P < .001). Moreover, FA (Pearson r = 0.428, Spearman r = 0.431; P < .001) and Ve (r = 0.226, P = .030 and r = 0.309, P = .003) in the anterior compartment and fat percentages in all three compartments (r = 0.481, 0.475, and 0.573; r = 0.515, 0.487, and 0.667; respectively; P < .001) were positively associated with age. Multiple regression analysis showed that age was predictive of fat percentage in the posterior compartment (β = 0.500, P < .001) and of FA in the anterior compartment (β = 0.194, P = .042). Interrater reliability was excellent (intraclass correlation coefficient, 0.745-0.992). Conclusion: Multiple MR imaging parameters were significantly associated with age in thigh muscles.

AB - Purpose: To use multiparametric magnetic resonance (MR) imaging to assess for and establish age-related differences in healthy thigh muscles. Materials and Methods: Ninety-five subjects (47 men, 48 women; median age, 47 years) with healthy body mass index were grouped according to age: 30-39 years (n = 25), 40-49 years (n = 25), 50-59 years (n = 25), and 60-69 years (n = 20). Multiparametric MR imaging (intravoxel incoherent motion diffusionweighted, diffusion-Tensor, multiecho Dixon, and dynamic contrast material-enhanced MR imaging) was performed at 3.0 T. Two radiologists independently evaluated parametric maps of the anterior, medial, and posterior compartments. Welch-modified one-way analysis of variance and post hoc Dunnet T3 test were used to evaluate differences in apparent diffusion, true diffusion, and pseudodiffusion coefficients; perfusion fraction; fractional anisotropy (FA); fat percentage; volume transfer constant; constant efflux rate from the extravascular-extracellular space to plasma; volume fraction of the extravascular-extracellular space (Ve); incremental area under the curve; and Pearson and Spearman correlation coefficients were used to evaluate relationship strength. Multiple regression analysis was performed to identify independent predictors of age, and interrater reliability was assessed with intraclass correlation coefficients. Results: There were significant differences among the age groups in apparent diffusion coefficients (P = .010), true diffusion coefficients (P = .045), FA (P < .001), Ve (P = .029) of the anterior compartment muscles, and fat percentages of all three compartments (P < .001). Moreover, FA (Pearson r = 0.428, Spearman r = 0.431; P < .001) and Ve (r = 0.226, P = .030 and r = 0.309, P = .003) in the anterior compartment and fat percentages in all three compartments (r = 0.481, 0.475, and 0.573; r = 0.515, 0.487, and 0.667; respectively; P < .001) were positively associated with age. Multiple regression analysis showed that age was predictive of fat percentage in the posterior compartment (β = 0.500, P < .001) and of FA in the anterior compartment (β = 0.194, P = .042). Interrater reliability was excellent (intraclass correlation coefficient, 0.745-0.992). Conclusion: Multiple MR imaging parameters were significantly associated with age in thigh muscles.

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