Multiple malignant extragastrointestinal stromal tumors of the greater omentum and results of immunohistochemistry and mutation analysis: A case report

Jong Han Kim, Yoon Jung Boo, Cheol Woong Jung, Sung Soo Park, Seung Joo Kim, Young Jae Mok, Sang Dae Kim, Yang Suk Chae, Chong Suk Kim

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

To report an extragastrointestinal stromal tumor (EGIST) that occurs outside the gastrointestinal tract and shows unique clinicopathologic and immunohistochemical features. In our case, we experienced multiple soft tissue tumors that originate primarily in the greater omentum, and in immunohistochemical analysis, the tumors showed features that correspond to malignant EGIST. Two large omental masses measured 15 cm × 10 cm and 5 cm × 4 cm sized and several small ovoid fragments were attached to small intestine, mesentery and peritoneum. On histologic findings, the masses were separated from small bowel serosa and had high mitotic count (115/50 HPFs). In the results of immunohistochemical stains, the tumor showed CD117 (c-kit) positive reactivity and high Ki-67 labeling index. On mutation analysis, the c-kit gene mutation was found in the juxtamembrane domain (exon 11) and it was heterozygote. Platelet-derived growth factor receptor (PDGFR) gene mutation was also found in the juxtamemembrane (exon 12) and it was polymorphism. From above findings, we proposed that there may be several mutational pathways to malignant EGIST, so further investigations could be needed to approach this unfavorable disease entity.

Original languageEnglish
Pages (from-to)3392-3395
Number of pages4
JournalWorld journal of gastroenterology
Volume13
Issue number24
DOIs
Publication statusPublished - 2007 Jun 28

Keywords

  • Extragastrointestinal stromal tumor
  • Greater omentum
  • Mutation
  • Platelet-derived growth factor receptor
  • c-kit

ASJC Scopus subject areas

  • Gastroenterology

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