Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex

Se Young Choi, Jeff Chang, Bin Jiang, Geun Hee Seol, Sun Seek Min, Jung Soo Han, Hee Sup Shin, Michela Gallagher, Alfredo Kirkwood

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Long-term depression (LTD) in sensory cortices depends on the activation of NMDA receptors. Here, we report that in visual cortical slices, the induction of LTD (but not long-term potentiation) also requires the activation of receptors coupled to the phospholipase C (PLC) pathway. Using immunolesions in combination with agonists and antagonists, we selectively manipulated the activation of α1 adrenergic, M1 muscarinic, and mGluR5 glutamatergic receptors. Inactivation of these PLC-coupled receptors prevents the induction of LTD, but only when the three receptors were inactivated together. LTD is fully restored by activating any one of them or by supplying intracellular D-myo-inositol-1,4,5-triphosphate (IP3). LTD was also impaired by intracellular application of PLC or IP3 receptor blockers, and it was absent in mice lacking PLCβ1, the predominant PLC isoform in the forebrain. We propose that visual cortical LTD requires a minimum of PLC activity that can be supplied independently by at least three neurotransmitter systems. This essential requirement places PLC-linked receptors in a unique position to control the induction of LTD and provides a mechanism for gating visual cortical plasticity via extra-retinal inputs in the intact organism.

Original languageEnglish
Pages (from-to)11433-11443
Number of pages11
JournalJournal of Neuroscience
Volume25
Issue number49
DOIs
Publication statusPublished - 2005 Dec 7
Externally publishedYes

Fingerprint

Type C Phospholipases
Visual Cortex
Inositol 1,4,5-Trisphosphate Receptors
Inositol 1,4,5-Trisphosphate
Long-Term Potentiation
Prosencephalon
N-Methyl-D-Aspartate Receptors
Adrenergic Agents
Cholinergic Agents
Neurotransmitter Agents
Protein Isoforms

Keywords

  • Adrenergic
  • Cholinergic
  • Glutamatergic
  • LTD
  • Neuromodulation
  • Plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex. / Choi, Se Young; Chang, Jeff; Jiang, Bin; Seol, Geun Hee; Min, Sun Seek; Han, Jung Soo; Shin, Hee Sup; Gallagher, Michela; Kirkwood, Alfredo.

In: Journal of Neuroscience, Vol. 25, No. 49, 07.12.2005, p. 11433-11443.

Research output: Contribution to journalArticle

Choi, SY, Chang, J, Jiang, B, Seol, GH, Min, SS, Han, JS, Shin, HS, Gallagher, M & Kirkwood, A 2005, 'Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex', Journal of Neuroscience, vol. 25, no. 49, pp. 11433-11443. https://doi.org/10.1523/JNEUROSCI.4084-05.2005
Choi, Se Young ; Chang, Jeff ; Jiang, Bin ; Seol, Geun Hee ; Min, Sun Seek ; Han, Jung Soo ; Shin, Hee Sup ; Gallagher, Michela ; Kirkwood, Alfredo. / Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex. In: Journal of Neuroscience. 2005 ; Vol. 25, No. 49. pp. 11433-11443.
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