Multiplexed DNA detection with DNA-functionalized silver and silver/gold nanoparticle superstructure probes

Ji Young Kim, Jae Seung Lee

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

DNA-functionalized silver and silver/gold bimetallic nanoparticle superstructure probes with controllable sizes and optical properties are synthesized using monothiol DNA and dithiothreitol. The superstructures exhibit a very narrow size distribution, which can be easily controlled by balancing the ratio of dithiothreitol and DNA. These superstructures assemble reversibly in a highly cooperative manner, and are SERS active. Multiplexed colorimetric detection of DNA targets using these superstructure probes has been demonstrated to identify three different DNA target sequences that are associated with three lethal diseases, respectively.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalBulletin of the Korean Chemical Society
Volume33
Issue number1
DOIs
Publication statusPublished - 2012 Jan 20

Keywords

  • Colorimetric detection
  • DNA
  • Multiplexing
  • Nanoparticle superstructure
  • SPR

ASJC Scopus subject areas

  • Chemistry(all)

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