Murine thymic stromal lymphopoietin promotes the differentiation of regulatory T cells from thymic CD4+CD8-CD25- naïve cells in a dendritic cell-independent manner

June Yong Lee, Yu Mi Lim, Min Jung Park, So Youn Min, Mi La Cho, Young Chul Sung, Se-Ho Park, Ho Youn Kim, Young Gyu Cho

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Human thymic stromal lymphopoietin (TSLP) activates dendritic cells (DCs), which promote the proliferation and differentiation of CD4+ T cells. However, murine TSLP (mTSLP) can act directly on CD4+ T cells and bring about their differentiation. We studied the role of mTSLP in the generation of CD4+CD25+FoxP3+ T cells from thymocytes. mTSLP promoted the differentiation of CD4+ single-positive thymocytes into CD4+CD25+FoxP3+ T cells. Although we cannot exclude an effect of TSLP mediated through DCs due to co-stimulatory effects, mTSLP appears to act directly on thymocytes. T-cell receptor and TSLP receptor signaling act synergistically on thymocytes to generate CD4+CD25+FoxP3+ T cells. mTSLP may play an important role in maintaining immune tolerance by promoting the conversion of thymocytes into natural regulatory T cells via escape from negative selection.

Original languageEnglish
Pages (from-to)206-213
Number of pages8
JournalImmunology and Cell Biology
Volume86
Issue number2
DOIs
Publication statusPublished - 2008 Feb 1

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Keywords

  • DCs
  • Negative selection
  • TCR
  • Treg
  • TSLP

ASJC Scopus subject areas

  • Immunology
  • Clinical Biochemistry
  • Cell Biology

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