Muscle weakness and myalgia as the initial presentation of serous ovarian carcinoma: A case report

Kyung Jin Min, Yung Taek Ouh, Hye Ri Hong, Kyeong A. So, Jin-Hwa Hong, Jae Kwan Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction. Epithelial ovarian cancer (EOC) has one of the worst prognoses among gynecologic cancers. An appropriate screening method is not available for EOC, and the initial symptoms such as abdominal pain or bloating, anorexia, and urinary urgency are vague. As a result, most cases of EOC are diagnosed at an advanced stage. Case presentation. We report novel insights gained from the case of a 45-year-old, gravida 0, para 0 woman who presented to the emergency department with complaints of general weakness, fatigue, and myalgia over the previous two months. She reported progressive muscle weakness of the upper and lower extremities leading to difficulty walking. Serum muscle enzymes, such as creatine phosphokinase, were markedly elevated. No evidence of malignancy was detected upon imaging. A biopsy of the left vastus medialis muscle was performed, and the results were consistent with primary myopathy with myofibrillar disarray, suggesting paraneoplastic necrotizing myopathy. Explorative laparotomy was performed to evaluate these results, and histopathological analysis of the full specimen revealed a grade 3 ovarian serous adenocarcinoma with direct invasion to the rectum. Conclusions: Because of the lack of screening tools for EOC, any clinical findings suggesting its presence are valuable, and the possibility of EOC should be considered in unknown primary malignancies with initial complaints of muscle weakness or myalgia.

Original languageEnglish
Article number43
JournalJournal of Ovarian Research
Volume7
Issue number1
DOIs
Publication statusPublished - 2014 Apr 23

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Myalgia
Muscle Weakness
Carcinoma
Mobility Limitation
Muscles
Neoplasms
Quadriceps Muscle
Anorexia
Muscular Diseases
Creatine Kinase
Rectum
Laparotomy
Abdominal Pain
Fatigue
Hospital Emergency Service
Lower Extremity
Adenocarcinoma
Ovarian epithelial cancer
Biopsy
Enzymes

Keywords

  • Ovarian carcinoma
  • Paraneoplastic necrotizing myopathy

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Muscle weakness and myalgia as the initial presentation of serous ovarian carcinoma : A case report. / Min, Kyung Jin; Ouh, Yung Taek; Hong, Hye Ri; So, Kyeong A.; Hong, Jin-Hwa; Lee, Jae Kwan.

In: Journal of Ovarian Research, Vol. 7, No. 1, 43, 23.04.2014.

Research output: Contribution to journalArticle

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