Mussel adhesion-employed water-immiscible fluid bioadhesive for urinary fistula sealing

Hyo Jeong Kim, Byeong Hee Hwang, Seonghye Lim, Bong Hyuk Choi, Seok Ho Kang, Hyung Joon Cha

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Urinary fistulas, abnormal openings of a urinary tract organ, are serious complications and conventional management strategies are not satisfactory. For more effective and non-invasive fistula repair, fluid tissue adhesives or sealants have been suggested. However, conventional products do not provide a suitable solution due to safety problems and poor underwater adhesion under physiological conditions. Herein, we proposed a unique water-immiscible mussel protein-based bioadhesive (WIMBA) exhibiting strong underwater adhesion which was employed by two adhesion strategies of marine organisms; 3,4-dihydroxy- l-phenylalanine (DOPA)-mediated strong adhesion and water-immiscible coacervation. The developed biocompatible WIMBA successfully sealed ex vivo urinary fistulas and provided good durability and high compliance. Thus, WIMBA could be used as a promising sealant for urinary fistula management with further expansion to diverse internal body applications.

Original languageEnglish
Pages (from-to)104-111
Number of pages8
JournalBiomaterials
Volume72
DOIs
Publication statusPublished - 2015 Jan 1

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Keywords

  • Complex coacervation
  • DOPA
  • Mussel adhesive proteins
  • Underwater adhesion
  • Urinary fistula

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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