Mussel adhesion-employed water-immiscible fluid bioadhesive for urinary fistula sealing

Hyo Jeong Kim, Byeong Hee Hwang, Seonghye Lim, Bong Hyuk Choi, Seok Ho Kang, Hyung Joon Cha

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Urinary fistulas, abnormal openings of a urinary tract organ, are serious complications and conventional management strategies are not satisfactory. For more effective and non-invasive fistula repair, fluid tissue adhesives or sealants have been suggested. However, conventional products do not provide a suitable solution due to safety problems and poor underwater adhesion under physiological conditions. Herein, we proposed a unique water-immiscible mussel protein-based bioadhesive (WIMBA) exhibiting strong underwater adhesion which was employed by two adhesion strategies of marine organisms; 3,4-dihydroxy- l-phenylalanine (DOPA)-mediated strong adhesion and water-immiscible coacervation. The developed biocompatible WIMBA successfully sealed ex vivo urinary fistulas and provided good durability and high compliance. Thus, WIMBA could be used as a promising sealant for urinary fistula management with further expansion to diverse internal body applications.

Original languageEnglish
Pages (from-to)104-111
Number of pages8
JournalBiomaterials
Volume72
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Urinary Fistula
Bivalvia
Adhesion
Fluids
Water
Sealants
Proteins
Tissue Adhesives
Aquatic Organisms
Urinary Tract
Phenylalanine
Compliance
Fistula
Adhesives
Durability
Repair
Tissue
Safety

Keywords

  • Complex coacervation
  • DOPA
  • Mussel adhesive proteins
  • Underwater adhesion
  • Urinary fistula

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Mussel adhesion-employed water-immiscible fluid bioadhesive for urinary fistula sealing. / Kim, Hyo Jeong; Hwang, Byeong Hee; Lim, Seonghye; Choi, Bong Hyuk; Kang, Seok Ho; Cha, Hyung Joon.

In: Biomaterials, Vol. 72, 01.01.2015, p. 104-111.

Research output: Contribution to journalArticle

Kim, Hyo Jeong ; Hwang, Byeong Hee ; Lim, Seonghye ; Choi, Bong Hyuk ; Kang, Seok Ho ; Cha, Hyung Joon. / Mussel adhesion-employed water-immiscible fluid bioadhesive for urinary fistula sealing. In: Biomaterials. 2015 ; Vol. 72. pp. 104-111.
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