Mutagenic activity of river water from a river near textile industrial complex in Korea

Jung Hwan Kwon, Hyun Kul Lee, Jin Wook Kwon, Kyun Kim, Eunju Park, Myung Hee Kang, Yong Hwa Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The mutagenic activity of XAD-2 adsorbates and water extracts recovered from nine locations of the Kumho River was tested on S. typhimurium TA98 strain to identify the source of the mutagenicity. A sampling site, receiving effluents from the textile industrial complex located in Daegu City, showed extraordinarily high mutagenic activity, especially in the presence of S9 mixture, at all sampling time in both XAD-2 adsorbates and dichloromethane extracts. This indicated the existence of the frame-shift mutagens in the Kumho River, same type of mutagens detected in previous studies by other researchers in the Nakdong River into which the Kumho River discharges. The fractionation study showed that the mutagenic chemicals in the river water are mid-polar. Furthermore, mean tail length obtained by single cell gel electrophoresis assay (Comet assay) showed consistent dose-dependent DNA damage, indicating that the chemicals in the river water not only act as frame-shift mutagens but also break human lymphocytes DNA strain. Chemical identification of the mutagens should be required.

Original languageEnglish
Pages (from-to)289-296
Number of pages8
JournalEnvironmental Monitoring and Assessment
Volume142
Issue number1-3
DOIs
Publication statusPublished - 2008 Jul
Externally publishedYes

Keywords

  • Comet assay
  • Genotoxicity
  • Mutagenicity
  • River water
  • Source identification
  • Textile industrial effluent

ASJC Scopus subject areas

  • Environmental Science(all)
  • Pollution
  • Management, Monitoring, Policy and Law

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