Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit: Generation of structural diversity at the benzoquinone ring

Woncheol Kim, Jong Suk Lee, Dongho Lee, Xing Fu Cai, Jin Chul Shin, Kyeong Lee, Choong Hwan Lee, Sangryeol Ryu, Sang Gi Paik, Jung Joon Lee, Young Soo Hong

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

(Chemical Equation Presented) A not so familiar ring. We describe results obtained from a mutasynthetic study based on geldanamycin (1), and demonstrate that this technique can be used to extend the structural diversity of the benzoquinone ring of 1. Our results show that geldanamycin PKS modules tolerate polyketide intermediate chains that bear unnatural benzoate components, and that they extend these structures further to produce mature polyketides (see scheme).

Original languageEnglish
Pages (from-to)1491-1494
Number of pages4
JournalChemBioChem
Volume8
Issue number13
DOIs
Publication statusPublished - 2007 Sep 3

Keywords

  • Ansamycin
  • Antitumor agents
  • Geldanamycin
  • Mutasynthesis
  • Polyketides

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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    Kim, W., Lee, J. S., Lee, D., Cai, X. F., Shin, J. C., Lee, K., Lee, C. H., Ryu, S., Paik, S. G., Lee, J. J., & Hong, Y. S. (2007). Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit: Generation of structural diversity at the benzoquinone ring. ChemBioChem, 8(13), 1491-1494. https://doi.org/10.1002/cbic.200700196