Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit

Generation of structural diversity at the benzoquinone ring

Woncheol Kim, Jong Suk Lee, Dongho Lee, Xing Fu Cai, Jin Chul Shin, Kyeong Lee, Choong Hwan Lee, Sangryeol Ryu, Sang Gi Paik, Jung Joon Lee, Young Soo Hong

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

(Chemical Equation Presented) A not so familiar ring. We describe results obtained from a mutasynthetic study based on geldanamycin (1), and demonstrate that this technique can be used to extend the structural diversity of the benzoquinone ring of 1. Our results show that geldanamycin PKS modules tolerate polyketide intermediate chains that bear unnatural benzoate components, and that they extend these structures further to produce mature polyketides (see scheme).

Original languageEnglish
Pages (from-to)1491-1494
Number of pages4
JournalChemBioChem
Volume8
Issue number13
DOIs
Publication statusPublished - 2007 Sep 3

Fingerprint

Polyketides
Starters
Genes
Benzoates
benzoquinone
geldanamycin

Keywords

  • Ansamycin
  • Antitumor agents
  • Geldanamycin
  • Mutasynthesis
  • Polyketides

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit : Generation of structural diversity at the benzoquinone ring. / Kim, Woncheol; Lee, Jong Suk; Lee, Dongho; Cai, Xing Fu; Shin, Jin Chul; Lee, Kyeong; Lee, Choong Hwan; Ryu, Sangryeol; Paik, Sang Gi; Lee, Jung Joon; Hong, Young Soo.

In: ChemBioChem, Vol. 8, No. 13, 03.09.2007, p. 1491-1494.

Research output: Contribution to journalArticle

Kim, W, Lee, JS, Lee, D, Cai, XF, Shin, JC, Lee, K, Lee, CH, Ryu, S, Paik, SG, Lee, JJ & Hong, YS 2007, 'Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit: Generation of structural diversity at the benzoquinone ring', ChemBioChem, vol. 8, no. 13, pp. 1491-1494. https://doi.org/10.1002/cbic.200700196
Kim, Woncheol ; Lee, Jong Suk ; Lee, Dongho ; Cai, Xing Fu ; Shin, Jin Chul ; Lee, Kyeong ; Lee, Choong Hwan ; Ryu, Sangryeol ; Paik, Sang Gi ; Lee, Jung Joon ; Hong, Young Soo. / Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit : Generation of structural diversity at the benzoquinone ring. In: ChemBioChem. 2007 ; Vol. 8, No. 13. pp. 1491-1494.
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