Mutation analysis of hepatitis B virus promoters in chronically infected children

Jeongwon Sohn, C. W. Lee, Jung Hwa Lee, Kwang Chul Lee, Chang Sung Son, J. W. Lee, Y. M. Ha-Lee

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Abstract

Hepatitis B viral (HBV) infection in early childhood is one of the leading causes of chronic hepatitis and liver cirrhosis that eventually lead to hepatic carcinoma. Despite the nationwide immunization programs to curtail the vertical transmission of HBV, childhood HBV infection through mothers is still occurring in Korea. As one of the efforts to understand the childhood HBV infection in Korea, four HBV promoter sequences in the sera of the chronically infected children were analyzed. Children harbored diverse viral variants as most of the chronically infected adult patients, but the deletion mutations were rare. The dominant viral sequences in the children were highly similar to the ones in the respective mothers, indicating that the maternal viruses were most likely transmitted to the children. The mutations in X, S1, S2/S promoters did not seem to show any correlation to the severity of the disease nor ages of the children. The mutations that showed some correlation to the severity of the disease were the mutations in C promoter, but the mutations did not seem to be vertically transmitted. Finally, the children with the elevated ALT/AST levels tended to have more child-specific variants suggesting that the accumulation of host-specific mutations might be associated with the development of clinical symptoms.

Original languageEnglish
Pages (from-to)1639-1651
Number of pages13
JournalArchives of Virology
Volume150
Issue number8
DOIs
Publication statusPublished - 2005 Aug 1

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Hepatitis B virus
Hepatitis B
Mutation
Virus Diseases
Mothers
Korea
Immunization Programs
Sequence Deletion
Chronic Hepatitis
Liver Cirrhosis
Viruses
Carcinoma
Liver
Serum

ASJC Scopus subject areas

  • Virology

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Mutation analysis of hepatitis B virus promoters in chronically infected children. / Sohn, Jeongwon; Lee, C. W.; Lee, Jung Hwa; Lee, Kwang Chul; Son, Chang Sung; Lee, J. W.; Ha-Lee, Y. M.

In: Archives of Virology, Vol. 150, No. 8, 01.08.2005, p. 1639-1651.

Research output: Contribution to journalArticle

Sohn, Jeongwon ; Lee, C. W. ; Lee, Jung Hwa ; Lee, Kwang Chul ; Son, Chang Sung ; Lee, J. W. ; Ha-Lee, Y. M. / Mutation analysis of hepatitis B virus promoters in chronically infected children. In: Archives of Virology. 2005 ; Vol. 150, No. 8. pp. 1639-1651.
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