Mutations in the human 5-lipoxygenase gene

Kwang Ho In, Eric S. Silverman, Koichiro Asano, David Beier, Andrew R. Fischer, Tim P. Keith, Kristina Serino, Chandri Yandava, George T. De Sanctis, Jeffrey M. Drazen

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Our data demonstrate the presence of a naturally occurring family of alleles in the core promoter of the 5-LO gene, which is characterized by the deletion or addition of consensus Sp1 (-GGGCGG) and Egr-1 (-GCGGGGGCG-) binding motifs. Each of the variant alleles can bind Sp1 and Egr-1 protein, as indicated by EMSA and supershift analysis with nuclear extracts. In addition, preliminary data from CAT reporter assays indicate that these alleles are less effective than the wild-type allele in initiating 5-LO gene expression. Whether patients harboring the various alleles identified herein have different capacities to transcribe the 5-LO gene and the importance of such potential regulation to the clinical expression of 5-LO have yet to be determined.

Original languageEnglish
Pages (from-to)59-69
Number of pages11
JournalClinical Reviews in Allergy and Immunology
Volume17
Issue number1-2
DOIs
Publication statusPublished - 1999 Jan 1
Externally publishedYes

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Arachidonate 5-Lipoxygenase
Alleles
Mutation
Genes
Gene Expression
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

In, K. H., Silverman, E. S., Asano, K., Beier, D., Fischer, A. R., Keith, T. P., ... Drazen, J. M. (1999). Mutations in the human 5-lipoxygenase gene. Clinical Reviews in Allergy and Immunology, 17(1-2), 59-69. https://doi.org/10.1007/BF02737597

Mutations in the human 5-lipoxygenase gene. / In, Kwang Ho; Silverman, Eric S.; Asano, Koichiro; Beier, David; Fischer, Andrew R.; Keith, Tim P.; Serino, Kristina; Yandava, Chandri; De Sanctis, George T.; Drazen, Jeffrey M.

In: Clinical Reviews in Allergy and Immunology, Vol. 17, No. 1-2, 01.01.1999, p. 59-69.

Research output: Contribution to journalReview article

In, KH, Silverman, ES, Asano, K, Beier, D, Fischer, AR, Keith, TP, Serino, K, Yandava, C, De Sanctis, GT & Drazen, JM 1999, 'Mutations in the human 5-lipoxygenase gene', Clinical Reviews in Allergy and Immunology, vol. 17, no. 1-2, pp. 59-69. https://doi.org/10.1007/BF02737597
In KH, Silverman ES, Asano K, Beier D, Fischer AR, Keith TP et al. Mutations in the human 5-lipoxygenase gene. Clinical Reviews in Allergy and Immunology. 1999 Jan 1;17(1-2):59-69. https://doi.org/10.1007/BF02737597
In, Kwang Ho ; Silverman, Eric S. ; Asano, Koichiro ; Beier, David ; Fischer, Andrew R. ; Keith, Tim P. ; Serino, Kristina ; Yandava, Chandri ; De Sanctis, George T. ; Drazen, Jeffrey M. / Mutations in the human 5-lipoxygenase gene. In: Clinical Reviews in Allergy and Immunology. 1999 ; Vol. 17, No. 1-2. pp. 59-69.
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