Mycobacterium tuberculosis lpdC, Rv0462, induces dendritic cell maturation and Th1 polarization

Deok Rim Heo, Sung Jae Shin, Woo Sik Kim, Kyung Tae Noh, Jin Wook Park, Kwang Hee Son, Won Sun Park, Min Goo Lee, Daejin Kim, Yong Kyoo Shin, In Duk Jung, Yeong Min Park

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    Mycobacterium tuberculosis, the etiological factor of pulmonary tuberculosis, causes significant morbidity and mortality worldwide. Activation of host immune responses for containment of mycobacterial infections involves participation of innate immune cells, such as dendritic cells (DCs). In this study, we demonstrated that the gene encoding lipoamide dehydrogenase C (lpdC) from M. tuberculosis, Rv0462, induce maturation and activation of DCs involved in the MAPKs signaling pathway. Moreover, Rv0462-treated DCs activated naïve T cells, polarized CD4+ and CD8+ T cells to secrete IFN-γ in syngeneic mixed lymphocyte reactions, which would be expected to contribute to Th1 polarization of the immune response. Our results suggest that Rv0462 can contribute to the innate and adaptive immune responses during tuberculosis infection, and thus modulate the clinical course of tuberculosis.

    Original languageEnglish
    Pages (from-to)642-647
    Number of pages6
    JournalBiochemical and biophysical research communications
    Volume411
    Issue number3
    DOIs
    Publication statusPublished - 2011 Aug 5

    Keywords

    • Dendritic cells
    • MAPKs
    • Mycobacterium tuberculosis
    • Rv0462
    • Th1 polarization

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

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