Mycophenolate mofetil as an alternative treatment for autoimmune hepatitis

Seung Woon Park, Soon Ho Um, Han Ah Lee, Sang Hyun Kim, Yura Sim, Sun Young Yim, Yeon Seok Seo, Ho Sang Ryu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Autoimmune hepatitis (AIH) is an immune-mediated chronic liver disease characterized by hepatocellular inflammation, necrosis, and fibrosis, which can progress to cirrhosis and fulminant hepatic failure. The standard treatment for AIH includes corticosteroids alone or in combination with azathioprine. Although most patients achieve remission using the standard regimen, some patients do not respond due to either drug intolerance or refractory disease; in such cases alternative immunosuppressive agents should be explored. The second-line therapies are cyclophilin inhibitors such as cyclosporine A or tacrolimus, and nowadays mycophenolate mofetil (MMF) is widely used if azathioprine-based therapies are not tolerated. Although these are recommended as an alternative to the first-line regimen, there is insufficient evidence for the efficacy of second-line therapies, with the evidence based mainly on expert opinion. Therefore, we report an AIH patient receiving the standard regimen in whom remission did not occur due to side effects to azathioprine, but was successfully treated with MMF in combination with corticosteroids as an alternative to the standard regimen.

Original languageEnglish
Pages (from-to)281-285
Number of pages5
JournalClinical and molecular hepatology
Volume22
Issue number2
DOIs
Publication statusPublished - 2016 Jun 1

Keywords

  • Autoimmune hepatitis
  • Azathioprine
  • Mycophenolate mofetil

ASJC Scopus subject areas

  • Medicine(all)

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