Mycophenolate mofetil as an alternative treatment for autoimmune hepatitis

Seung Woon Park, Soon Ho Um, Han Ah Lee, Sang Hyun Kim, Yura Sim, Sun Young Yim, Yeon Seok Seo, Ho Sang Ryu

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    Autoimmune hepatitis (AIH) is an immune-mediated chronic liver disease characterized by hepatocellular inflammation, necrosis, and fibrosis, which can progress to cirrhosis and fulminant hepatic failure. The standard treatment for AIH includes corticosteroids alone or in combination with azathioprine. Although most patients achieve remission using the standard regimen, some patients do not respond due to either drug intolerance or refractory disease; in such cases alternative immunosuppressive agents should be explored. The second-line therapies are cyclophilin inhibitors such as cyclosporine A or tacrolimus, and nowadays mycophenolate mofetil (MMF) is widely used if azathioprine-based therapies are not tolerated. Although these are recommended as an alternative to the first-line regimen, there is insufficient evidence for the efficacy of second-line therapies, with the evidence based mainly on expert opinion. Therefore, we report an AIH patient receiving the standard regimen in whom remission did not occur due to side effects to azathioprine, but was successfully treated with MMF in combination with corticosteroids as an alternative to the standard regimen.

    Original languageEnglish
    Pages (from-to)281-285
    Number of pages5
    JournalClinical and molecular hepatology
    Volume22
    Issue number2
    DOIs
    Publication statusPublished - 2016 Jun 1

    Keywords

    • Autoimmune hepatitis
    • Azathioprine
    • Mycophenolate mofetil

    ASJC Scopus subject areas

    • Medicine(all)

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