Myricetin inhibits endometriosis growth through cyclin E1 down-regulation in vitro and in vivo

Sunwoo Park, Gwonhwa Song, Whasun Lim

Research output: Contribution to journalArticle

Abstract

Endometriosis is a benign gynecological condition prevalent among reproductive-aged women. Although active research and studies have been carried out to discover new drugs, surgery and hormone therapy are still the gold standard for endometriosis treatment. Nowadays, various flavonoids are considered long-term supplements for different diseases. Myricetin, a flavonol, has antiproliferative, anti- or pro-oxidant, and anticancer effects in gynecological diseases. Here, we reveal for the first time, to our knowledge, the antigrowth effects of myricetin in endometriosis. Myricetin inhibited cell proliferation and cell cycle progression of human VK2/E6E7 and End1/E6E7 cells and induced apoptosis, with the loss of mitochondrial membrane potential and accumulation of reactive oxygen species and calcium ions. Additionally, myricetin decreased the activation of AKT and ERK1/2 proteins, whereas it induced p38 activation in both cell lines. Moreover, myricetin decreased lesion size in the endometriosis mouse model via Ccne1 inhibition. Thus, myricetin has antiproliferative effects on endometriosis through cell cycle regulation.

Original languageEnglish
Article number108328
JournalJournal of Nutritional Biochemistry
Volume78
DOIs
Publication statusPublished - 2020 Apr

Keywords

  • Antiproliferation
  • CCNE1
  • Cell cycle
  • Endometriosis
  • Myricetin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Nutrition and Dietetics
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Myricetin inhibits endometriosis growth through cyclin E1 down-regulation in vitro and in vivo'. Together they form a unique fingerprint.

  • Cite this