Myricetin suppresses invasion and promotes cell death in human placental choriocarcinoma cells through induction of oxidative stress

Changwon Yang, Whasun Lim, Fuller W. Bazer, Gwonhwa Song

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Myricetin is a bioactive compound found in a variety of vegetables and fruits, and its anti-cancer effects are well known. In this study, we confirmed that myricetin reduced proliferation of two choriocarcinoma cell lines (JAR and JEG-3) and also promoted apoptosis and regulated cell cycle progression in a dose-dependent manner in JAR and JEG-3 cells. In addition, we found that invasive and pro-angiogenic properties of malignant JAR and JEG-3 trophoblast cells were attenuated by myricetin treatment via MAPK and PI3K/AKT signaling pathways. In addition, we found that ROS production, lipid peroxidation, glutathione depletion, and loss of mitochondrial membrane potentials were enhanced in JAR and JEG-3 cells treated with myricetin. Moreover, myricetin augmented cytosolic Ca2+ release from the endoplasmic reticulum associated with modulation of ER stress in JAR and JEG-3 cells. Our results also revealed that myricetin had synergistic antiproliferative effects with current chemotherapeutics, etoposide and cisplatin, on choriocarcinoma cells. Collectively, results of the present study provide strong evidence for the potential of myricetin to be an effective therapeutic for the prevention of human placental choriocarcinomas.

Original languageEnglish
Pages (from-to)10-19
Number of pages10
JournalCancer Letters
Volume399
DOIs
Publication statusPublished - 2017 Jul 28

Fingerprint

Choriocarcinoma
Oxidative stress
Cell death
Oxidative Stress
Cell Death
Cells
Mitochondrial Membrane Potential
Vegetables
Trophoblasts
Etoposide
Fruits
myricetin
Phosphatidylinositol 3-Kinases
Endoplasmic Reticulum
Cisplatin
Lipid Peroxidation
Glutathione
Fruit
Cell Cycle
Modulation

Keywords

  • Apoptosis
  • Choriocarcinoma
  • Invasion
  • Myricetin
  • ROS

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Myricetin suppresses invasion and promotes cell death in human placental choriocarcinoma cells through induction of oxidative stress. / Yang, Changwon; Lim, Whasun; Bazer, Fuller W.; Song, Gwonhwa.

In: Cancer Letters, Vol. 399, 28.07.2017, p. 10-19.

Research output: Contribution to journalArticle

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