N′-(phenyl-2-yl-methylene)-hydrazine carbodithioic acid methyl ester enhances radiation-induced cell death by targeting Bcl-2 against human lung carcinoma cells

Jong Kuk Park, Young Min Chung, Byung Gyu Kim, Young A. Yoo, Beom Seok Yang, Jun Suk Kim, Young Do Yoo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To develop a new radiosensitizer, we screened a chemical library and selected one chemical reagent, N′-(phenyl-pyridin-2-yl-methylene)-hydrazine carbodithioic acid methyl ester (PHCM), which was already known to have antifungal and antimicrobial properties. PHCM enhanced radiation-induced cell death and its mean calculated dose enhancement ratio was 1.17. PHCM was found to induce the phosphorylation of p38 mitogen-activated protein kinase, and combined treatment with PHCM and radiation down-regulated Bcl-2. In a xenograft assay, the combined PHCM and radiation group showed 39.3 days of growth delay versus the control in terms of tumor growth. The enhancement factor of this combined treatment was determined to be 4.02.

Original languageEnglish
Pages (from-to)403-407
Number of pages5
JournalMolecular Cancer Therapeutics
Volume3
Issue number4
Publication statusPublished - 2004 Apr 1

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hydrazine
Esters
Cell Death
Radiation
Carcinoma
Lung
Acids
Small Molecule Libraries
p38 Mitogen-Activated Protein Kinases
Growth
Heterografts
Phosphorylation
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Drug Discovery
  • Pharmacology

Cite this

N′-(phenyl-2-yl-methylene)-hydrazine carbodithioic acid methyl ester enhances radiation-induced cell death by targeting Bcl-2 against human lung carcinoma cells. / Park, Jong Kuk; Chung, Young Min; Kim, Byung Gyu; Yoo, Young A.; Yang, Beom Seok; Kim, Jun Suk; Yoo, Young Do.

In: Molecular Cancer Therapeutics, Vol. 3, No. 4, 01.04.2004, p. 403-407.

Research output: Contribution to journalArticle

Park, Jong Kuk ; Chung, Young Min ; Kim, Byung Gyu ; Yoo, Young A. ; Yang, Beom Seok ; Kim, Jun Suk ; Yoo, Young Do. / N′-(phenyl-2-yl-methylene)-hydrazine carbodithioic acid methyl ester enhances radiation-induced cell death by targeting Bcl-2 against human lung carcinoma cells. In: Molecular Cancer Therapeutics. 2004 ; Vol. 3, No. 4. pp. 403-407.
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