Nano-interstice driven powerless blood plasma extraction in a membrane filter integrated microfluidic device

Jaehoon Kim, Junghyo Yoon, Jae Yeong Byun, Hyunho Kim, Sewoon Han, Junghyun Kim, Jeong Hoon Lee, Han Sang Jo, Seok Chung

Research output: Contribution to journalArticlepeer-review

Abstract

Blood plasma is a source of biomarkers in blood and a simple, fast, and easy extraction method is highly required for point-of-care testing (POCT) applications. This paper proposes a membrane filter integrated microfluidic device to extract blood plasma from whole blood, without any external instrumentation. A commercially available membrane filter was integrated with a newly designed dual-cover microfluidic device to avoid leakage of the extracted plasma and remaining blood cells. Nano-interstices installed on both sides of the microfluidic channels actively draw the extracted plasma from the membrane. The developed device successfully supplied 20 μl of extracted plasma with a high extraction yield (~45%) in 16 min.

Original languageEnglish
Article number1366
Pages (from-to)1-19
Number of pages19
JournalSensors (Switzerland)
Volume21
Issue number4
DOIs
Publication statusPublished - 2021 Feb 2

Keywords

  • Blood plasma extraction
  • Microfluidics
  • Point-of-care testing

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Electrical and Electronic Engineering

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