Nano metamaterials for ultrasensitive Terahertz biosensing

Dong Kyu Lee, Ji Hun Kang, Junghoon Kwon, Jun Seok Lee, Seok Lee, Deok Ha Woo, Jae Hun Kim, Chang Seon Song, Q Han Park, Minah Seo

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

As a candidate for a rapid detection of biomaterials, terahertz (THz) spectroscopy system can be considered with some advantage in non-destructive, label-free, and non-contact manner. Because protein-ligand binding energy is in the THz range, especially, most important conformational information in molecular interactions can be captured by THz electromagnetic wave. Based on the THz time-domain spectroscopy system, THz nano-metamaterial sensing chips were prepared for great enhancing of detection sensitivity. A metamaterial sensing chip was designed for increasing of absorption cross section of the target sample, related to the transmitted THz near field enhancement via the composition of metamaterial. The measured THz optical properties were then analyzed in terms of refractive index and absorption coefficient, and compared with simulation results. Also, virus quantification regarding various concentrations of the viruses was performed, showing a clear linearity. The proposed sensitive and selective THz detection method can provide abundant information of detected biomaterials to help deep understanding of fundamental optical characteristics of them, suggesting rapid diagnosis way especially useful for such dangerous and time-sensitive target biomaterials.

Original languageEnglish
Article number8146
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - 2017 Dec 1

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viruses
chips
molecular interactions
absorption cross sections
spectroscopy
linearity
near fields
absorptivity
electromagnetic radiation
binding energy
refractivity
proteins
optical properties
ligands
augmentation
coefficients
simulation

ASJC Scopus subject areas

  • General

Cite this

Lee, D. K., Kang, J. H., Kwon, J., Lee, J. S., Lee, S., Woo, D. H., ... Seo, M. (2017). Nano metamaterials for ultrasensitive Terahertz biosensing. Scientific Reports, 7(1), [8146]. https://doi.org/10.1038/s41598-017-08508-7

Nano metamaterials for ultrasensitive Terahertz biosensing. / Lee, Dong Kyu; Kang, Ji Hun; Kwon, Junghoon; Lee, Jun Seok; Lee, Seok; Woo, Deok Ha; Kim, Jae Hun; Song, Chang Seon; Park, Q Han; Seo, Minah.

In: Scientific Reports, Vol. 7, No. 1, 8146, 01.12.2017.

Research output: Contribution to journalArticle

Lee, DK, Kang, JH, Kwon, J, Lee, JS, Lee, S, Woo, DH, Kim, JH, Song, CS, Park, QH & Seo, M 2017, 'Nano metamaterials for ultrasensitive Terahertz biosensing', Scientific Reports, vol. 7, no. 1, 8146. https://doi.org/10.1038/s41598-017-08508-7
Lee DK, Kang JH, Kwon J, Lee JS, Lee S, Woo DH et al. Nano metamaterials for ultrasensitive Terahertz biosensing. Scientific Reports. 2017 Dec 1;7(1). 8146. https://doi.org/10.1038/s41598-017-08508-7
Lee, Dong Kyu ; Kang, Ji Hun ; Kwon, Junghoon ; Lee, Jun Seok ; Lee, Seok ; Woo, Deok Ha ; Kim, Jae Hun ; Song, Chang Seon ; Park, Q Han ; Seo, Minah. / Nano metamaterials for ultrasensitive Terahertz biosensing. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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