Nano-structured chitosan self-aggregates as a drug delivery carrier

Min Su Bae, Ick Chan Kwon, Seo Young Jeong, Kuen Yong Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Colloidal delivery systems including polymeric self-aggregates have been widely investigated to date, as these formulations may reduce unwanted side effects and may improve the therapeutic effects. Various characteristics of self-aggregates prepared from deoxycholic acid-modified chitosan were investigated by fluorescence spectroscopic and dynamic light scattering methods, and found to be controlled by the degree of substitution of hydrophobic groups, and pH and ionic strength of the medium. Chitosan self-aggregates can form complexes with plasmid DNA, and can be used to transfect COS-1 cells in vitro. Adriamycin can be also entrapped into chitosan self-aggregates and released in a sustained manner in vitro. These self-aggregates may find potential applications as a delivery vehicle of genes and anti-cancer drugs.

Original languageEnglish
Title of host publication2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings
EditorsM. Laudon, B. Romanowicz
Pages164-167
Number of pages4
Publication statusPublished - 2005
Event2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 - Anaheim, CA, United States
Duration: 2005 May 82005 May 12

Publication series

Name2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings

Other

Other2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005
CountryUnited States
CityAnaheim, CA
Period05/5/805/5/12

Keywords

  • Adriamycin
  • Chitosan
  • DNA
  • Self-aggregates

ASJC Scopus subject areas

  • Engineering(all)

Fingerprint Dive into the research topics of 'Nano-structured chitosan self-aggregates as a drug delivery carrier'. Together they form a unique fingerprint.

  • Cite this

    Bae, M. S., Kwon, I. C., Jeong, S. Y., & Lee, K. Y. (2005). Nano-structured chitosan self-aggregates as a drug delivery carrier. In M. Laudon, & B. Romanowicz (Eds.), 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings (pp. 164-167). (2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings).