Nanobubbles from gas-generating polymeric nanoparticles: Ultrasound imaging of living subjects

Eunah Kang; Hyun Su Min; Jaeyoung Lee; Moon Hee Han; Hyung Jun Ahn; In Chan Yoon; Kuiwon Choi; Kwangmeyoung Kim; Kinam Park; Ick Chan Kwon

doi:10.1002/anie.200903841

Nanobubbles from gas-generating polymeric nanoparticles: Ultrasound imaging of living subjects

Eunah Kang, Hyun Su Min, Jaeyoung Lee, Moon Hee Han, Hyung Jun Ahn, In Chan Yoon, Kuiwon Choi, Kwangmeyoung Kim, Kinam Park, Ick Chan Kwon

KU-KIST Graduate School of Converging Science and Technology

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

(Figure Presented) A bubbly personality: Coalescence and fusion of carbon dioxide nanobubbles in a tumor leads to microbubbles that can be imaged by ultrasound (see picture). The bubbles are released from gas-generating polymeric nanoparticles that are coated with hydrophobically modified chitosan. Hydrolysis of the polymer poly(BL-PO), which consists of a biodegradable main backbone and a carbonate side chain, results in the release of carbon dioxide.

Original language	English
Pages (from-to)	524-528
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	3
DOIs	https://doi.org/10.1002/anie.200903841
Publication status	Published - 2010 Jan 12

Keywords

Carbon dioxide
Imaging agents
Nanostructures
Polymers
Ultrasound

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200903841

Cite this

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abstract = "(Figure Presented) A bubbly personality: Coalescence and fusion of carbon dioxide nanobubbles in a tumor leads to microbubbles that can be imaged by ultrasound (see picture). The bubbles are released from gas-generating polymeric nanoparticles that are coated with hydrophobically modified chitosan. Hydrolysis of the polymer poly(BL-PO), which consists of a biodegradable main backbone and a carbonate side chain, results in the release of carbon dioxide.",

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AU - Ahn, Hyung Jun

AU - Yoon, In Chan

AU - Choi, Kuiwon

AU - Kim, Kwangmeyoung

AU - Park, Kinam

AU - Kwon, Ick Chan

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AB - (Figure Presented) A bubbly personality: Coalescence and fusion of carbon dioxide nanobubbles in a tumor leads to microbubbles that can be imaged by ultrasound (see picture). The bubbles are released from gas-generating polymeric nanoparticles that are coated with hydrophobically modified chitosan. Hydrolysis of the polymer poly(BL-PO), which consists of a biodegradable main backbone and a carbonate side chain, results in the release of carbon dioxide.

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KW - Imaging agents

KW - Nanostructures

KW - Polymers

KW - Ultrasound

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Nanobubbles from gas-generating polymeric nanoparticles: Ultrasound imaging of living subjects

Abstract

Keywords

ASJC Scopus subject areas

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