Nanobubbles from gas-generating polymeric nanoparticles: Ultrasound imaging of living subjects

Eunah Kang, Hyun Su Min, Jaeyoung Lee, Moon Hee Han, Hyung Jun Ahn, In Chan Yoon, Kuiwon Choi, Kwangmeyoung Kim, Kinam Park, Ick Chan Kwon

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

(Figure Presented) A bubbly personality: Coalescence and fusion of carbon dioxide nanobubbles in a tumor leads to microbubbles that can be imaged by ultrasound (see picture). The bubbles are released from gas-generating polymeric nanoparticles that are coated with hydrophobically modified chitosan. Hydrolysis of the polymer poly(BL-PO), which consists of a biodegradable main backbone and a carbonate side chain, results in the release of carbon dioxide.

Original languageEnglish
Pages (from-to)524-528
Number of pages5
JournalAngewandte Chemie - International Edition
Volume49
Issue number3
DOIs
Publication statusPublished - 2010 Jan 12

Keywords

  • Carbon dioxide
  • Imaging agents
  • Nanostructures
  • Polymers
  • Ultrasound

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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    Kang, E., Min, H. S., Lee, J., Han, M. H., Ahn, H. J., Yoon, I. C., Choi, K., Kim, K., Park, K., & Kwon, I. C. (2010). Nanobubbles from gas-generating polymeric nanoparticles: Ultrasound imaging of living subjects. Angewandte Chemie - International Edition, 49(3), 524-528. https://doi.org/10.1002/anie.200903841