Nanofibrous scaffolds electrospun from elastomeric biodegradable poly(L-lactide-co-ε-caprolactone) copolymer

Sangwon Chung, Ajit K. Moghe, Gerardo A. Montero, Soo Hyun Kim, Martin W. King

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Electrospinning has recently received much attention in biomedical applications, and has shown great potential as a novel scaffold fabrication method for tissue engineering. The nano scale diameter of the fibers produced and the structure of the web resemble certain supramolecular features of extracellular matrix which is favorable for cell attachment, growth and proliferation. There are various parameters that can alter the electrospinning process, and varying one or more of these conditions will result in producing different nanofibrous webs. So the aim of this study was to investigate the effect of material variables and process variables on the morphology of electrospun 50:50 poly(L-lactide-co-ε-caprolactone) (PLCL) nanofibrous structures. The morphology of the nanofibers produced was strongly influenced by parameters such as the flow rate of the polymer solution, the electrospinning voltage and the solution concentration. The diameter was found to increase with solution concentration in a direct linear relationship. Finally, it has been successfully demonstrated that by increasing the rotation speed of the collector mandrel, the alignment of the fibers can be controlled in a preferred direction. These findings contribute to determining the functional conditions to electrospin this biodegradable elastomeric copolymer which has potential as a scaffold material for vascular tissue engineering.

Original languageEnglish
Article number015019
JournalBiomedical Materials
Volume4
Issue number1
DOIs
Publication statusPublished - 2009 Aug 12
Externally publishedYes

Fingerprint

Electrospinning
Scaffolds
Copolymers
Bioelectric potentials
Tissue Engineering
Scaffolds (biology)
Tissue engineering
Nanofibers
Fibers
Polymer solutions
Extracellular Matrix
Blood Vessels
Polymers
Flow rate
Fabrication
Electric potential
Growth
elastomeric
poly(lactide)
caprolactone

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Business and International Management
  • Mechanics of Materials
  • Medicine(all)

Cite this

Nanofibrous scaffolds electrospun from elastomeric biodegradable poly(L-lactide-co-ε-caprolactone) copolymer. / Chung, Sangwon; Moghe, Ajit K.; Montero, Gerardo A.; Kim, Soo Hyun; King, Martin W.

In: Biomedical Materials, Vol. 4, No. 1, 015019, 12.08.2009.

Research output: Contribution to journalArticle

Chung, Sangwon ; Moghe, Ajit K. ; Montero, Gerardo A. ; Kim, Soo Hyun ; King, Martin W. / Nanofibrous scaffolds electrospun from elastomeric biodegradable poly(L-lactide-co-ε-caprolactone) copolymer. In: Biomedical Materials. 2009 ; Vol. 4, No. 1.
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