Nanomechanical Motion of Microcantilevers Driven by Ion-Induced DNA Conformational Transitions

Kilho Eom, Huihun Jung, Suho Jeong, Chi Hyun Kim, Dae Sung Yoon, Taeyun Kwon

Research output: Contribution to journalArticle

Abstract

In this paper, we report the nanomechanical motion of a microcantilever due to the conformational transitions of DNA molecules that are functionalized on the surface of a microcantilever. In particular, the conformational transitions of DNA molecules can be induced by the change of ionic concentrations, which results in the bending deflection motion of a microcantilever. It is shown that a cantilever-DNA hybrid system is able to sense and detect the chemical environment changes such as pH change and/or ionic concentration change, and also that microscale device such as microcantilever can be actuated using molecular conformational changes. Our study provides a new insight into the development of a novel nano-bio-hybrid system based on microdevice coupled with molecular motors for chemical sensing as well as chemical-driven actuation.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalBioNanoScience
Volume1
Issue number4
DOIs
Publication statusPublished - 2011 Dec
Externally publishedYes

Keywords

  • Bending deflection motion
  • Conformational change
  • DNA motor
  • Ion sensing
  • Microcantilever

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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