Nanoparticle formulation for controlled release of capsaicin

Seon Kim, Jong Chul Kim, Dong Geun Sul, Sun Wook Hwang, Sang Heon Lee, Young Ha Kim, Giyoong Tae

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Capsaicin might be an effective pharmacological agent for the treatment of discogenic back pain due to its effect on pain control neuronal degeneration. Therefore, capsaicin-loaded nano-and micro-particles for sustained release were formulated by nano-precipitation or oil-in-water single emulsion solvent evaporation/extraction method. First, the capsaicin-loaded PLGA nanoparticles were prepared by nano-precipitation method. By increasing the volume of oil-water ratio from 1:2 to 1:5, slight changes in size from 162±3 nm to 153±3 nm and in drug loading efficiency from 25% to 20% were observed, whereas the drug release period was significantly changed from 11 days for 1:2 to 5 days for 1:5 ratio. To get a more sustained release, a modified single emulsion method was applied with three kinds of biocompatible polymers (PLLA, PLGA, and PCL). Among them, PLLA particles showed a much sustained release profile than PLGA or PCL ones with the similar size. For PLLA particles, particles size and drug encapsulation efficiency increased as the oil/water ratio decreased, and the bigger particles showed the slower release profiles as well as the higher drugloading efficiency, thus about 1 month release was obtained with 800 nm particles. In conclusion, formulation for the controlled release of capsaicin from 1 week to 1 month was prepared by using biocompatible nanoparticles.

Original languageEnglish
Pages (from-to)4586-4591
Number of pages6
JournalJournal of Nanoscience and Nanotechnology
Volume11
Issue number5
DOIs
Publication statusPublished - 2011 May 1

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Keywords

  • Capsaicin
  • Controlled release
  • Nanoparticle
  • PLLA

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Chemistry(all)
  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering

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