@article{f73921e1190744a38cdcf5d8a0f3c2a0,
title = "Nanoscale materials-based platforms for the treatment of bone-related diseases",
abstract = "Owing to the high density of bone tissue and the complex and highly hierarchical structure, drugs used for the treatment of bone-related diseases are often not effectively concentrated at the site of the lesion. Generally, the therapeutic effect is unsatisfactory, and the long-term use of drugs causes adverse effects. Therefore, it is of great importance to explore nanotherapeutic platforms to improve bone-targeting capabilities and provide controlled release performance on demand to enhance therapeutic effects. This review aims to (1) summarize various types of recently developed nanotherapeutic platforms; (2) present representative material strategies for applying nanoplatforms for treating bone diseases based on a deeper knowledge of the biophysical structure and material-chemical composition of human osteology, and the awareness of disease pathogenesis and progression; and (3) summarize the typical multifunctional systems through a suitable combination of different cues for enhancing the treatment efficacy.",
keywords = "2D nanomaterial, arthritis, bone cancer, bone fracture, nanoparticle, osteoporosis, scaffold",
author = "Xiaodi Zhang and Seyoung Koo and Kim, {Ji Hyeon} and Xiangang Huang and Na Kong and Liqun Zhang and Jun Zhou and Jiajia Xue and Harris, {Mitchel B.} and Wei Tao and Kim, {Jong Seung}",
note = "Funding Information: We acknowledge support from a US METAvivor Early Career Investigator Award (Grant No. 2018A020560; W.T.), a Harvard Medical School Brigham and Women's Hospital Department of Anesthesiology Basic Scientist Grant (Grant No. 2420 BPA075; W.T.), a Khoury Innovation Award (Grant No. 2020A003219; W.T.), a Gillian Reny Stepping Strong Center for Trauma Innovation Breakthrough Innovator Award (Grant No. 113548; W.T.), an American Heart Association Collaborative Science Award (No. 2018A004190; W.T.), a CRI project of the National Research Foundation of Korea (Grant No. 2018R1A3B1052702, J.S.K.), the National Natural Science Foundation of China (Grant No. 52073014 and 82002049; J.X.), the Key Program of Beijing Natural Science Foundation (Grant No. Z200025; J.X.), the Basic Science Research Program (2020R1A6A3A01100558, S.K.), and the Global PhD Fellowship (GPF) program (2019H1A2A1074096, J.H.K.). W.T. also received a start-up package (for 3 years) from the Department of Anesthesiology, Perioperative and Pain Medicine to establish his independent research laboratory at Harvard Medical School and Brigham and Women's Hospital. We thank our department for this generous support. J.S.K. W.T. M.B.H. and J.X. proposed the topic of the review. X.Z. S.K. J.H.K. and X.H. investigated the literature and prepared the manuscript. N.K. and L.Z. helped to revise the manuscript. J.S.K. W.T. and J.X. guided the overall structure and content of the review. The authors declare no competing interests. Funding Information: We acknowledge support from a US METAvivor Early Career Investigator Award (Grant No. 2018A020560 ; W.T.), a Harvard Medical School Brigham and Women's Hospital Department of Anesthesiology Basic Scientist Grant (Grant No. 2420 BPA075 ; W.T.), a Khoury Innovation Award (Grant No. 2020A003219 ; W.T.), a Gillian Reny Stepping Strong Center for Trauma Innovation Breakthrough Innovator Award (Grant No. 113548 ; W.T.), an American Heart Association Collaborative Science Award (No. 2018A004190 ; W.T.), a CRI project of the National Research Foundation of Korea (Grant No. 2018R1A3B1052702 , J.S.K.), the National Natural Science Foundation of China (Grant No. 52073014 and 82002049 ; J.X.), the Key Program of Beijing Natural Science Foundation (Grant No. Z200025 ; J.X.), the Basic Science Research Program ( 2020R1A6A3A01100558 , S.K.), and the Global PhD Fellowship (GPF) program ( 2019H1A2A1074096 , J.H.K.). W.T. also received a start-up package (for 3 years) from the Department of Anesthesiology, Perioperative and Pain Medicine to establish his independent research laboratory at Harvard Medical School and Brigham and Women's Hospital. We thank our department for this generous support. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = sep,
day = "1",
doi = "10.1016/j.matt.2021.05.019",
language = "English",
volume = "4",
pages = "2727--2764",
journal = "Matter",
issn = "2590-2393",
publisher = "Cell Press",
number = "9",
}
