Nanoscale materials-based platforms for the treatment of bone-related diseases

Xiaodi Zhang, Seyoung Koo, Ji Hyeon Kim, Xiangang Huang, Na Kong, Liqun Zhang, Jun Zhou, Jiajia Xue, Mitchel B. Harris, Wei Tao, Jong Seung Kim

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

Owing to the high density of bone tissue and the complex and highly hierarchical structure, drugs used for the treatment of bone-related diseases are often not effectively concentrated at the site of the lesion. Generally, the therapeutic effect is unsatisfactory, and the long-term use of drugs causes adverse effects. Therefore, it is of great importance to explore nanotherapeutic platforms to improve bone-targeting capabilities and provide controlled release performance on demand to enhance therapeutic effects. This review aims to (1) summarize various types of recently developed nanotherapeutic platforms; (2) present representative material strategies for applying nanoplatforms for treating bone diseases based on a deeper knowledge of the biophysical structure and material-chemical composition of human osteology, and the awareness of disease pathogenesis and progression; and (3) summarize the typical multifunctional systems through a suitable combination of different cues for enhancing the treatment efficacy.

Original languageEnglish
Pages (from-to)2727-2764
Number of pages38
JournalMatter
Volume4
Issue number9
DOIs
Publication statusPublished - 2021 Sep 1

Keywords

  • 2D nanomaterial
  • arthritis
  • bone cancer
  • bone fracture
  • nanoparticle
  • osteoporosis
  • scaffold

ASJC Scopus subject areas

  • Materials Science(all)

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