Nasal polyps and future risk of head and neck cancer: A nationwide population-based cohort study

Hyun Jung Kim, Hyeong Sik Ahn, T. Kang, C. Bachert, Woo Jung Song

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Nasal polyps are a common condition with a significant effect on quality of life. The association between nasal polyps and future risk of head and neck cancer is unknown. Objective: We sought to investigate the relative risk of nasal cavity and paranasal sinus (NCPS) and nasopharyngeal cancers in a nationwide, population-based, longitudinal retrospective cohort of patients with nasal polyps and matched comparators. Methods: The 2005-2017 National Health Insurance claims and National Health Screening program databases were used to construct a cohort of patients with nasal polyps and matched comparators in Korea. The relative risk of NCPS and nasopharyngeal cancer in patients with nasal polyps was examined. Results: The study consisted of 453,892 patients with nasal polyps and 4,583,938 matched comparators. The mean duration of follow-up was 6.2 years (range, 2-13 years). The incidence rate ratios of patients with nasal polyps compared with the comparators was 7.00 (95% CI, 5.28-9.25) for NCPS cancer and 1.78 (95% CI, 1.28-2.42) for nasopharyngeal cancer. Increased risks of these cancers were only evident in older subjects (age ≥50 years). There were trends toward weaker associations of nasal polyps with these cancers in younger subjects with comorbid asthma or allergic rhinitis (<50 years). Conclusion: Although the absolute cancer incidence is very low, the relative risk of NCPS or nasopharyngeal cancers was significantly greater in older patients with nasal polyps. Given the regional and pathologic heterogeneity of nasal polyps, further studies are needed to explore the underlying mechanisms and validate the relationships.

Original languageEnglish
JournalJournal of Allergy and Clinical Immunology
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Nasal Polyps
Head and Neck Neoplasms
Cohort Studies
Paranasal Sinus Neoplasms
Nasopharyngeal Neoplasms
Population
Paranasal Sinuses
Nasal Cavity
National Health Programs
Neoplasms
Incidence
Korea
Asthma
Quality of Life
Databases

Keywords

  • cancer risk
  • head and neck cancer
  • Nasal polyps
  • nasopharyngeal neoplasms
  • paranasal sinus neoplasms

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Nasal polyps and future risk of head and neck cancer : A nationwide population-based cohort study. / Kim, Hyun Jung; Ahn, Hyeong Sik; Kang, T.; Bachert, C.; Song, Woo Jung.

In: Journal of Allergy and Clinical Immunology, 01.01.2019.

Research output: Contribution to journalArticle

@article{05dc1f978315463088ddf9417c1e74a4,
title = "Nasal polyps and future risk of head and neck cancer: A nationwide population-based cohort study",
abstract = "Background: Nasal polyps are a common condition with a significant effect on quality of life. The association between nasal polyps and future risk of head and neck cancer is unknown. Objective: We sought to investigate the relative risk of nasal cavity and paranasal sinus (NCPS) and nasopharyngeal cancers in a nationwide, population-based, longitudinal retrospective cohort of patients with nasal polyps and matched comparators. Methods: The 2005-2017 National Health Insurance claims and National Health Screening program databases were used to construct a cohort of patients with nasal polyps and matched comparators in Korea. The relative risk of NCPS and nasopharyngeal cancer in patients with nasal polyps was examined. Results: The study consisted of 453,892 patients with nasal polyps and 4,583,938 matched comparators. The mean duration of follow-up was 6.2 years (range, 2-13 years). The incidence rate ratios of patients with nasal polyps compared with the comparators was 7.00 (95{\%} CI, 5.28-9.25) for NCPS cancer and 1.78 (95{\%} CI, 1.28-2.42) for nasopharyngeal cancer. Increased risks of these cancers were only evident in older subjects (age ≥50 years). There were trends toward weaker associations of nasal polyps with these cancers in younger subjects with comorbid asthma or allergic rhinitis (<50 years). Conclusion: Although the absolute cancer incidence is very low, the relative risk of NCPS or nasopharyngeal cancers was significantly greater in older patients with nasal polyps. Given the regional and pathologic heterogeneity of nasal polyps, further studies are needed to explore the underlying mechanisms and validate the relationships.",
keywords = "cancer risk, head and neck cancer, Nasal polyps, nasopharyngeal neoplasms, paranasal sinus neoplasms",
author = "Kim, {Hyun Jung} and Ahn, {Hyeong Sik} and T. Kang and C. Bachert and Song, {Woo Jung}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.jaci.2019.06.024",
language = "English",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",

}

TY - JOUR

T1 - Nasal polyps and future risk of head and neck cancer

T2 - A nationwide population-based cohort study

AU - Kim, Hyun Jung

AU - Ahn, Hyeong Sik

AU - Kang, T.

AU - Bachert, C.

AU - Song, Woo Jung

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Nasal polyps are a common condition with a significant effect on quality of life. The association between nasal polyps and future risk of head and neck cancer is unknown. Objective: We sought to investigate the relative risk of nasal cavity and paranasal sinus (NCPS) and nasopharyngeal cancers in a nationwide, population-based, longitudinal retrospective cohort of patients with nasal polyps and matched comparators. Methods: The 2005-2017 National Health Insurance claims and National Health Screening program databases were used to construct a cohort of patients with nasal polyps and matched comparators in Korea. The relative risk of NCPS and nasopharyngeal cancer in patients with nasal polyps was examined. Results: The study consisted of 453,892 patients with nasal polyps and 4,583,938 matched comparators. The mean duration of follow-up was 6.2 years (range, 2-13 years). The incidence rate ratios of patients with nasal polyps compared with the comparators was 7.00 (95% CI, 5.28-9.25) for NCPS cancer and 1.78 (95% CI, 1.28-2.42) for nasopharyngeal cancer. Increased risks of these cancers were only evident in older subjects (age ≥50 years). There were trends toward weaker associations of nasal polyps with these cancers in younger subjects with comorbid asthma or allergic rhinitis (<50 years). Conclusion: Although the absolute cancer incidence is very low, the relative risk of NCPS or nasopharyngeal cancers was significantly greater in older patients with nasal polyps. Given the regional and pathologic heterogeneity of nasal polyps, further studies are needed to explore the underlying mechanisms and validate the relationships.

AB - Background: Nasal polyps are a common condition with a significant effect on quality of life. The association between nasal polyps and future risk of head and neck cancer is unknown. Objective: We sought to investigate the relative risk of nasal cavity and paranasal sinus (NCPS) and nasopharyngeal cancers in a nationwide, population-based, longitudinal retrospective cohort of patients with nasal polyps and matched comparators. Methods: The 2005-2017 National Health Insurance claims and National Health Screening program databases were used to construct a cohort of patients with nasal polyps and matched comparators in Korea. The relative risk of NCPS and nasopharyngeal cancer in patients with nasal polyps was examined. Results: The study consisted of 453,892 patients with nasal polyps and 4,583,938 matched comparators. The mean duration of follow-up was 6.2 years (range, 2-13 years). The incidence rate ratios of patients with nasal polyps compared with the comparators was 7.00 (95% CI, 5.28-9.25) for NCPS cancer and 1.78 (95% CI, 1.28-2.42) for nasopharyngeal cancer. Increased risks of these cancers were only evident in older subjects (age ≥50 years). There were trends toward weaker associations of nasal polyps with these cancers in younger subjects with comorbid asthma or allergic rhinitis (<50 years). Conclusion: Although the absolute cancer incidence is very low, the relative risk of NCPS or nasopharyngeal cancers was significantly greater in older patients with nasal polyps. Given the regional and pathologic heterogeneity of nasal polyps, further studies are needed to explore the underlying mechanisms and validate the relationships.

KW - cancer risk

KW - head and neck cancer

KW - Nasal polyps

KW - nasopharyngeal neoplasms

KW - paranasal sinus neoplasms

UR - http://www.scopus.com/inward/record.url?scp=85069932416&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069932416&partnerID=8YFLogxK

U2 - 10.1016/j.jaci.2019.06.024

DO - 10.1016/j.jaci.2019.06.024

M3 - Article

C2 - 31279013

AN - SCOPUS:85069932416

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

ER -