National cholesterol education panel III guidelines performance role in preventing myocardial infarction in a large cohort without a history of coronary artery disease: Korea acute myocardial infarction registry study

Yeonyee E. Yoon, Juan J. Rivera, Dong A. Kwon, In Ho Chae, Myung Ho Jeong, Seung-Woon Rha, Roger S. Blumenthal, Khurram Nasir, Hyuk Jae Chang

Research output: Contribution to journalArticle

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Abstract

The Third Report of the Adult Treatment Panel National Cholesterol Education Program (NCEP-ATPIII) guidelines are widely used for the primary prevention of a coronary event. These guidelines were developed using experimental data from studies that enrolled mostly Caucasian patients. The pathogenesis of atherosclerosis varies with ethnicity. Given these two circumstances, the authors sought to investigate the performance of the guidelines in a large Asian cohort. The Korea Acute Myocardial Infarction Registry (KAMIR) includes data collected between November 2005 and December 2006 from 41 referral centers in South Korea. A retrospective review of the clinical data was performed. After patients with a history of coronary heart disease (CHD), CHD equivalent, and those taking lipid-lowering medications were excluded, 2969 individuals (76% men; 61±12 years) were enrolled. The recommendations for lipid-lowering treatments according to the NCEP-ATPIII were examined in the context of the cohort. A total of 38%, 66%, and 8% of the study participants had hypertension, were smokers, and had a family history of premature CHD, respectively. When patients were stratified by the number of risk factors present and their 10-year CHD risk, 69% diagnosed with an acute myocardial infarction did not qualify for drug therapy. Irrespective of the age group examined (young, intermediate, and old), the percentage of patients who did not qualify for a lipid-lowering pharmacologic intervention was higher than 60%. NCEP-ATPIII underestimates CHD risk in individuals of Asian descent. Further studies are needed to improve primary CHD prevention in this patient population.

Original languageEnglish
Pages (from-to)109-113
Number of pages5
JournalPreventive Cardiology
Volume12
Issue number2
DOIs
Publication statusPublished - 2009 Mar 1

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Korea
Coronary Disease
Registries
Coronary Artery Disease
Myocardial Infarction
Cholesterol
Guidelines
Education
Lipids
Republic of Korea
Primary Prevention
Atherosclerosis
Referral and Consultation
Age Groups
Hypertension
Drug Therapy
Therapeutics
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Public Health, Environmental and Occupational Health

Cite this

National cholesterol education panel III guidelines performance role in preventing myocardial infarction in a large cohort without a history of coronary artery disease : Korea acute myocardial infarction registry study. / Yoon, Yeonyee E.; Rivera, Juan J.; Kwon, Dong A.; Chae, In Ho; Jeong, Myung Ho; Rha, Seung-Woon; Blumenthal, Roger S.; Nasir, Khurram; Chang, Hyuk Jae.

In: Preventive Cardiology, Vol. 12, No. 2, 01.03.2009, p. 109-113.

Research output: Contribution to journalArticle

Yoon, Yeonyee E. ; Rivera, Juan J. ; Kwon, Dong A. ; Chae, In Ho ; Jeong, Myung Ho ; Rha, Seung-Woon ; Blumenthal, Roger S. ; Nasir, Khurram ; Chang, Hyuk Jae. / National cholesterol education panel III guidelines performance role in preventing myocardial infarction in a large cohort without a history of coronary artery disease : Korea acute myocardial infarction registry study. In: Preventive Cardiology. 2009 ; Vol. 12, No. 2. pp. 109-113.
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