Natural compounds from danshen suppress the activity of hepatic stellate cells

Hwan Oh Seong, Kyung Hwan Cho, Beom Seok Yang, Kyun Roh Yong

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Danshen is an herbal medication frequently used in oriental medicine to treat liver or kidney malfunction. In the course of our studies, we observed that compounds purified from Danshen exhibit an inhibitory activity against Discoidin Domain Receptor 2 (DDR2) tyrosine kinase. Through this inhibition, these compounds also inhibited the growth of HSC T6 cells and suppressed the expression of alpha-smooth muscle actin and MMP2, as well as collagen synthesis, all of which are increased in activated liver stellate cells. Given that activation of liver stellate cells is the hallmark of liver fibrosis and that DDR2 plays a critical role in this activation, these results suggest that one of the pharmacological activities of Danshen extract that protects the liver is the inhibition of key cell-signaling kinases, such as DDR2, in liver stellate cells.

Original languageEnglish
Pages (from-to)762-767
Number of pages6
JournalArchives of pharmacal research
Volume29
Issue number9
DOIs
Publication statusPublished - 2006 Sep 30

Keywords

  • Danshen
  • Fibrosis
  • Kinase inhibitor
  • Liver stellate cell

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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