Natural compounds from danshen suppress the activity of hepatic stellate cells

Hwan Oh Seong, Kyung-Hwan Cho, Beom Seok Yang, Kyun Roh Yong

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Danshen is an herbal medication frequently used in oriental medicine to treat liver or kidney malfunction. In the course of our studies, we observed that compounds purified from Danshen exhibit an inhibitory activity against Discoidin Domain Receptor 2 (DDR2) tyrosine kinase. Through this inhibition, these compounds also inhibited the growth of HSC T6 cells and suppressed the expression of alpha-smooth muscle actin and MMP2, as well as collagen synthesis, all of which are increased in activated liver stellate cells. Given that activation of liver stellate cells is the hallmark of liver fibrosis and that DDR2 plays a critical role in this activation, these results suggest that one of the pharmacological activities of Danshen extract that protects the liver is the inhibition of key cell-signaling kinases, such as DDR2, in liver stellate cells.

Original languageEnglish
Pages (from-to)762-767
Number of pages6
JournalArchives of Pharmacal Research
Volume29
Issue number9
Publication statusPublished - 2006 Sep 30

Fingerprint

Salvia miltiorrhiza
Hepatic Stellate Cells
Liver
East Asian Traditional Medicine
Chemical activation
TYK2 Kinase
Cell signaling
Liver Cirrhosis
Smooth Muscle
Actins
Phosphotransferases
Collagen
Medicine
Muscle
Pharmacology
Kidney
Growth
Discoidin Domain Receptor 2

Keywords

  • Danshen
  • Fibrosis
  • Kinase inhibitor
  • Liver stellate cell

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Natural compounds from danshen suppress the activity of hepatic stellate cells. / Seong, Hwan Oh; Cho, Kyung-Hwan; Yang, Beom Seok; Yong, Kyun Roh.

In: Archives of Pharmacal Research, Vol. 29, No. 9, 30.09.2006, p. 762-767.

Research output: Contribution to journalArticle

Seong, Hwan Oh ; Cho, Kyung-Hwan ; Yang, Beom Seok ; Yong, Kyun Roh. / Natural compounds from danshen suppress the activity of hepatic stellate cells. In: Archives of Pharmacal Research. 2006 ; Vol. 29, No. 9. pp. 762-767.
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