TY - JOUR
T1 - Natural history of low-grade squamous intraepithelial lesion
AU - Saw, H. S.
AU - Lee, Jae Kwan
AU - Lee, H. L.
AU - Jee, H. J.
AU - Hyun, Jong Jin
PY - 2001/12/27
Y1 - 2001/12/27
N2 - Objective. To determine guidelines for management of CIN1 by evaluating its natural history. Methods. One hundred fifty-eight patients were diagnosed with CIN1 had colposcopy follow-up with or without cytology every three months. Results. Colposcopically directed biopsy confirmed progression to CIN2 or CIN3 in 17 of 158 (10.7%) patients, persistence of CIN1 in 87 (55%) patients, regression to normal in 54 (34.2%) patients during the 5-year follow-up period. The percentage of abnormal Pap tests were 39%, 64%, and 71% in the regression, persistent, and progression groups, respectively. The percentage of HPV-positive tests were 16%, 29%, 65% in regression, persistent, and progression groups, respectively. Conclusions. Of the patients who were diagnosed with CIN1 and monitored by colposcopy for 60 months, 34% had disease regression, 55% had persistent disease, and 11% had progressive disease. HPV DNA testing is more informative than the Pap test in the prediction of disease progression.
AB - Objective. To determine guidelines for management of CIN1 by evaluating its natural history. Methods. One hundred fifty-eight patients were diagnosed with CIN1 had colposcopy follow-up with or without cytology every three months. Results. Colposcopically directed biopsy confirmed progression to CIN2 or CIN3 in 17 of 158 (10.7%) patients, persistence of CIN1 in 87 (55%) patients, regression to normal in 54 (34.2%) patients during the 5-year follow-up period. The percentage of abnormal Pap tests were 39%, 64%, and 71% in the regression, persistent, and progression groups, respectively. The percentage of HPV-positive tests were 16%, 29%, 65% in regression, persistent, and progression groups, respectively. Conclusions. Of the patients who were diagnosed with CIN1 and monitored by colposcopy for 60 months, 34% had disease regression, 55% had persistent disease, and 11% had progressive disease. HPV DNA testing is more informative than the Pap test in the prediction of disease progression.
KW - HPV DNA test
KW - LGSIL
KW - Natural history
UR - http://www.scopus.com/inward/record.url?scp=0035214861&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035214861&partnerID=8YFLogxK
U2 - 10.1046/j.1526-0976.2001.53007.x
DO - 10.1046/j.1526-0976.2001.53007.x
M3 - Article
C2 - 17050960
AN - SCOPUS:0035214861
VL - 5
SP - 153
EP - 158
JO - Journal of Lower Genital Tract Disease
JF - Journal of Lower Genital Tract Disease
SN - 1089-2591
IS - 3
ER -