Natural iridoids from Patrinia heterophylla showing anti-inflammatory activities in vitro and in vivo

Peng Wu, Ziteng Song, Ying Li, Huimei Wang, Han Zhang, Jiahe Bao, Yuhao Li, Jianlin Cui, Da Qing Jin, Aijie Wang, Bin Liang, Dongho Lee, Jing Xu, Yuanqiang Guo

Research output: Contribution to journalArticlepeer-review

Abstract

Inflammation, especially chronic inflammation, has been found to be closely related to the pathology of many diseases and the discovery of bioactive natural products to inhibit NO production is one of strategies to treat inflammation. In our continuous search for bioactive natural substances as potential anti-inflammatory agents, five new compounds (1–5) were extracted and purified from Patrinia heterophylla. The NMR and MS data analysis, along with electronic circular dichroism (ECD) calculations, led to the identification of these isolates, which were new iridoids. Using cell and zebrafish models, the in vitro and in vivo anti-inflammatory effects were conducted to evaluate the potency of anti-inflammation of these compounds. The preliminary mechanism was explored using molecular docking and Western blotting experiments.

Original languageEnglish
Article number104331
JournalBioorganic Chemistry
Volume104
DOIs
Publication statusPublished - 2020 Nov

Keywords

  • Anti-inflammatory potency
  • Iridoids
  • NO inhibition
  • Patrinia heterophylla
  • Zebrafish model

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

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