@article{2f2332e2a4944751a85b60f4ddeca622,
title = "Natural iridoids from Patrinia heterophylla showing anti-inflammatory activities in vitro and in vivo",
abstract = "Inflammation, especially chronic inflammation, has been found to be closely related to the pathology of many diseases and the discovery of bioactive natural products to inhibit NO production is one of strategies to treat inflammation. In our continuous search for bioactive natural substances as potential anti-inflammatory agents, five new compounds (1–5) were extracted and purified from Patrinia heterophylla. The NMR and MS data analysis, along with electronic circular dichroism (ECD) calculations, led to the identification of these isolates, which were new iridoids. Using cell and zebrafish models, the in vitro and in vivo anti-inflammatory effects were conducted to evaluate the potency of anti-inflammation of these compounds. The preliminary mechanism was explored using molecular docking and Western blotting experiments.",
keywords = "Anti-inflammatory potency, Iridoids, NO inhibition, Patrinia heterophylla, Zebrafish model",
author = "Peng Wu and Ziteng Song and Ying Li and Huimei Wang and Han Zhang and Jiahe Bao and Yuhao Li and Jianlin Cui and Jin, {Da Qing} and Aijie Wang and Bin Liang and Dongho Lee and Jing Xu and Yuanqiang Guo",
note = "Funding Information: This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107 , 22077067 , and U1801288 ), the Natural Science Foundation of Tianjin , China (No. 19JCYBJC28100 ), the Hundred Young Academic Leaders Program of Nankai University , and the Open Project of Key Laboratory of Environmental Biotechnology, Chinese Academy of Sciences (Grant No. kf2019006 ). Funding Information: This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107, 22077067, and U1801288), the Natural Science Foundation of Tianjin, China (No. 19JCYBJC28100), the Hundred Young Academic Leaders Program of Nankai University, and the Open Project of Key Laboratory of Environmental Biotechnology, Chinese Academy of Sciences (Grant No. kf2019006). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = nov,
doi = "10.1016/j.bioorg.2020.104331",
language = "English",
volume = "104",
journal = "Bioorganic Chemistry",
issn = "0045-2068",
publisher = "Academic Press Inc.",
}