Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury

Alexander J. Davies, Hyoung Woo Kim, Rafael Gonzalez-Cano, Jahyang Choi, Seung Keun Back, Seung Eon Roh, Errin Johnson, Melanie Gabriac, Mi Sun Kim, Jaehee Lee, Jeong Eun Lee, Yun Sook Kim, Yong Chul Bae, Sang Jeong Kim, Kyung-Mi Lee, Heung Sik Na, Priscilla Riva, Alban Latremoliere, Simon Rinaldi, Sophie UgoliniMichael Costigan, Seog Bae Oh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Sensory axons degenerate following separation from their cell body, but partial injury to peripheral nerves may leave the integrity of damaged axons preserved. We show that an endogenous ligand for the natural killer (NK) cell receptor NKG2D, Retinoic Acid Early 1 (RAE1), is re-expressed in adult dorsal root ganglion neurons following peripheral nerve injury, triggering selective degeneration of injured axons. Infiltration of cytotoxic NK cells into the sciatic nerve by extravasation occurs within 3 days following crush injury. Using a combination of genetic cell ablation and cytokine-antibody complex stimulation, we show that NK cell function correlates with loss of sensation due to degeneration of injured afferents and reduced incidence of post-injury hypersensitivity. This neuro-immune mechanism of selective NK cell-mediated degeneration of damaged but intact sensory axons complements Wallerian degeneration and suggests the therapeutic potential of modulating NK cell function to resolve painful neuropathy through the clearance of partially damaged nerves.

Original languageEnglish
Pages (from-to)716-728.e18
JournalCell
Volume176
Issue number4
DOIs
Publication statusPublished - 2019 Feb 7

Fingerprint

Natural Killer Cells
Axons
Peripheral Nerve Injuries
Wounds and Injuries
Natural Killer Cell Receptors
Wallerian Degeneration
Spinal Ganglia
Sciatic Nerve
Ablation
Tretinoin
Infiltration
Neurons
Hypersensitivity
Cells
Cytokines
Ligands
Antibodies
Incidence
Therapeutics

Keywords

  • autoimmunity
  • dorsal root ganglia
  • innate immunity
  • natural cytotoxicity
  • neurodegeneration
  • neuroimmune
  • neuropathic pain
  • peripheral neuropathy
  • sciatic nerve crush
  • Wallerian degeneration

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Davies, A. J., Kim, H. W., Gonzalez-Cano, R., Choi, J., Back, S. K., Roh, S. E., ... Oh, S. B. (2019). Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury. Cell, 176(4), 716-728.e18. https://doi.org/10.1016/j.cell.2018.12.022

Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury. / Davies, Alexander J.; Kim, Hyoung Woo; Gonzalez-Cano, Rafael; Choi, Jahyang; Back, Seung Keun; Roh, Seung Eon; Johnson, Errin; Gabriac, Melanie; Kim, Mi Sun; Lee, Jaehee; Lee, Jeong Eun; Kim, Yun Sook; Bae, Yong Chul; Kim, Sang Jeong; Lee, Kyung-Mi; Na, Heung Sik; Riva, Priscilla; Latremoliere, Alban; Rinaldi, Simon; Ugolini, Sophie; Costigan, Michael; Oh, Seog Bae.

In: Cell, Vol. 176, No. 4, 07.02.2019, p. 716-728.e18.

Research output: Contribution to journalArticle

Davies, AJ, Kim, HW, Gonzalez-Cano, R, Choi, J, Back, SK, Roh, SE, Johnson, E, Gabriac, M, Kim, MS, Lee, J, Lee, JE, Kim, YS, Bae, YC, Kim, SJ, Lee, K-M, Na, HS, Riva, P, Latremoliere, A, Rinaldi, S, Ugolini, S, Costigan, M & Oh, SB 2019, 'Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury', Cell, vol. 176, no. 4, pp. 716-728.e18. https://doi.org/10.1016/j.cell.2018.12.022
Davies AJ, Kim HW, Gonzalez-Cano R, Choi J, Back SK, Roh SE et al. Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury. Cell. 2019 Feb 7;176(4):716-728.e18. https://doi.org/10.1016/j.cell.2018.12.022
Davies, Alexander J. ; Kim, Hyoung Woo ; Gonzalez-Cano, Rafael ; Choi, Jahyang ; Back, Seung Keun ; Roh, Seung Eon ; Johnson, Errin ; Gabriac, Melanie ; Kim, Mi Sun ; Lee, Jaehee ; Lee, Jeong Eun ; Kim, Yun Sook ; Bae, Yong Chul ; Kim, Sang Jeong ; Lee, Kyung-Mi ; Na, Heung Sik ; Riva, Priscilla ; Latremoliere, Alban ; Rinaldi, Simon ; Ugolini, Sophie ; Costigan, Michael ; Oh, Seog Bae. / Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury. In: Cell. 2019 ; Vol. 176, No. 4. pp. 716-728.e18.
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