Natural killer T cells promote collagen-induced arthritis in DBA/1 mice

Sundo Jung, Hyun suk Shin, Changwan Hong, Hyunji Lee, Yoon Kyung Park, Jung Hoon Shin, Seokmann Hong, Gap Ryol Lee, Se-Ho Park

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The role of NKT cells in the pathogenesis of collagen-induced arthritis (CIA) remains unclear since most studies have used C57BL/6 (B6) mice, which are less susceptible to CIA than mice with a DBA/1 background. To clarify the immunological functions of NKT cells in CIA, it is necessary to analyze in detail the effects of NKT cell deficiency on CIA development in DBA/1 mice. The incidence and severity of CIA were significantly exacerbated in DBA/1CD1d+/- mice as compared to DBA/1CD1d-/- mice. In DBA/1CD1d+/- mice, antigen-specific responses of B and T cells against CII were remarkably increased and inflammatory cytokine levels were also increased in vivo and in vitro. The number of IL-17-producing NKT cells significantly increased in DBA/1CD1d+/- mice as the disease progressed. Our results clearly show that NKT cells are involved not only in accelerating the severity and incidence of CIA but also in perpetuating the disease progression.

Original languageEnglish
Pages (from-to)399-403
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume390
Issue number3
DOIs
Publication statusPublished - 2009 Dec 18

Fingerprint

Inbred DBA Mouse
Natural Killer T-Cells
Experimental Arthritis
T-cells
Collagen
Interleukin-17
Incidence
Disease Progression
B-Lymphocytes
Cytokines
T-Lymphocytes
Antigens

Keywords

  • Autoimmune disease
  • CIA
  • IL-17
  • NKT cells
  • Th1/Th2 balance

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Natural killer T cells promote collagen-induced arthritis in DBA/1 mice. / Jung, Sundo; Shin, Hyun suk; Hong, Changwan; Lee, Hyunji; Park, Yoon Kyung; Shin, Jung Hoon; Hong, Seokmann; Lee, Gap Ryol; Park, Se-Ho.

In: Biochemical and Biophysical Research Communications, Vol. 390, No. 3, 18.12.2009, p. 399-403.

Research output: Contribution to journalArticle

Jung, Sundo ; Shin, Hyun suk ; Hong, Changwan ; Lee, Hyunji ; Park, Yoon Kyung ; Shin, Jung Hoon ; Hong, Seokmann ; Lee, Gap Ryol ; Park, Se-Ho. / Natural killer T cells promote collagen-induced arthritis in DBA/1 mice. In: Biochemical and Biophysical Research Communications. 2009 ; Vol. 390, No. 3. pp. 399-403.
@article{f941045a03c84d0c9423e3aebfa9fb39,
title = "Natural killer T cells promote collagen-induced arthritis in DBA/1 mice",
abstract = "The role of NKT cells in the pathogenesis of collagen-induced arthritis (CIA) remains unclear since most studies have used C57BL/6 (B6) mice, which are less susceptible to CIA than mice with a DBA/1 background. To clarify the immunological functions of NKT cells in CIA, it is necessary to analyze in detail the effects of NKT cell deficiency on CIA development in DBA/1 mice. The incidence and severity of CIA were significantly exacerbated in DBA/1CD1d+/- mice as compared to DBA/1CD1d-/- mice. In DBA/1CD1d+/- mice, antigen-specific responses of B and T cells against CII were remarkably increased and inflammatory cytokine levels were also increased in vivo and in vitro. The number of IL-17-producing NKT cells significantly increased in DBA/1CD1d+/- mice as the disease progressed. Our results clearly show that NKT cells are involved not only in accelerating the severity and incidence of CIA but also in perpetuating the disease progression.",
keywords = "Autoimmune disease, CIA, IL-17, NKT cells, Th1/Th2 balance",
author = "Sundo Jung and Shin, {Hyun suk} and Changwan Hong and Hyunji Lee and Park, {Yoon Kyung} and Shin, {Jung Hoon} and Seokmann Hong and Lee, {Gap Ryol} and Se-Ho Park",
year = "2009",
month = "12",
day = "18",
doi = "10.1016/j.bbrc.2009.09.008",
language = "English",
volume = "390",
pages = "399--403",
journal = "The BMJ",
issn = "0730-6512",
publisher = "Kluwer Academic Publishers",
number = "3",

}

TY - JOUR

T1 - Natural killer T cells promote collagen-induced arthritis in DBA/1 mice

AU - Jung, Sundo

AU - Shin, Hyun suk

AU - Hong, Changwan

AU - Lee, Hyunji

AU - Park, Yoon Kyung

AU - Shin, Jung Hoon

AU - Hong, Seokmann

AU - Lee, Gap Ryol

AU - Park, Se-Ho

PY - 2009/12/18

Y1 - 2009/12/18

N2 - The role of NKT cells in the pathogenesis of collagen-induced arthritis (CIA) remains unclear since most studies have used C57BL/6 (B6) mice, which are less susceptible to CIA than mice with a DBA/1 background. To clarify the immunological functions of NKT cells in CIA, it is necessary to analyze in detail the effects of NKT cell deficiency on CIA development in DBA/1 mice. The incidence and severity of CIA were significantly exacerbated in DBA/1CD1d+/- mice as compared to DBA/1CD1d-/- mice. In DBA/1CD1d+/- mice, antigen-specific responses of B and T cells against CII were remarkably increased and inflammatory cytokine levels were also increased in vivo and in vitro. The number of IL-17-producing NKT cells significantly increased in DBA/1CD1d+/- mice as the disease progressed. Our results clearly show that NKT cells are involved not only in accelerating the severity and incidence of CIA but also in perpetuating the disease progression.

AB - The role of NKT cells in the pathogenesis of collagen-induced arthritis (CIA) remains unclear since most studies have used C57BL/6 (B6) mice, which are less susceptible to CIA than mice with a DBA/1 background. To clarify the immunological functions of NKT cells in CIA, it is necessary to analyze in detail the effects of NKT cell deficiency on CIA development in DBA/1 mice. The incidence and severity of CIA were significantly exacerbated in DBA/1CD1d+/- mice as compared to DBA/1CD1d-/- mice. In DBA/1CD1d+/- mice, antigen-specific responses of B and T cells against CII were remarkably increased and inflammatory cytokine levels were also increased in vivo and in vitro. The number of IL-17-producing NKT cells significantly increased in DBA/1CD1d+/- mice as the disease progressed. Our results clearly show that NKT cells are involved not only in accelerating the severity and incidence of CIA but also in perpetuating the disease progression.

KW - Autoimmune disease

KW - CIA

KW - IL-17

KW - NKT cells

KW - Th1/Th2 balance

UR - http://www.scopus.com/inward/record.url?scp=70449718748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70449718748&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2009.09.008

DO - 10.1016/j.bbrc.2009.09.008

M3 - Article

VL - 390

SP - 399

EP - 403

JO - The BMJ

JF - The BMJ

SN - 0730-6512

IS - 3

ER -