Natural NO inhibitors from the leaves of Callicarpa kwangtungensis: Structures, activities, and interactions with iNOS

Shen Li, Xiaocong Sun, Yang Li, Feng Liu, Jun Ma, Ling Tong, Guochen Su, Jing Xu, Yasushi Ohizumi, Dongho Lee, Yuanqiang Guo

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A phytochemical investigation to obtain new NO inhibitors resulted in the isolation of a new diterpenoid with a rare 9,10-seco-abietane skeleton (1) and twelve known terpenoids (2–13) from Callicarpa kwangtungensis. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analyses, and the absolute configuration of compound 1 was established by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. The inhibitory activities on lipopolysaccharide-induced NO production in murine microglial BV-2 cells of these terpenoids were evaluated, and all of the compounds showed inhibitory effects. The following molecular docking studies showed interactions of the bioactive compounds with the iNOS protein.

Original languageEnglish
Pages (from-to)670-674
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume27
Issue number3
DOIs
Publication statusPublished - 2017 Feb 1

Keywords

  • 9,10-seco-Abietane diterpenoid
  • Callicarpa kwangtungensis
  • iNOS
  • Molecular docking
  • NO inhibitory activities
  • Terpenoids

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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