TY - JOUR
T1 - Natural NO inhibitors from the leaves of Callicarpa kwangtungensis
T2 - Structures, activities, and interactions with iNOS
AU - Li, Shen
AU - Sun, Xiaocong
AU - Li, Yang
AU - Liu, Feng
AU - Ma, Jun
AU - Tong, Ling
AU - Su, Guochen
AU - Xu, Jing
AU - Ohizumi, Yasushi
AU - Lee, Dongho
AU - Guo, Yuanqiang
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (No. 21372125), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), and the State Key Laboratory of Medicinal Chemical Biology (No. 201602007).
PY - 2017
Y1 - 2017
N2 - A phytochemical investigation to obtain new NO inhibitors resulted in the isolation of a new diterpenoid with a rare 9,10-seco-abietane skeleton (1) and twelve known terpenoids (2–13) from Callicarpa kwangtungensis. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analyses, and the absolute configuration of compound 1 was established by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. The inhibitory activities on lipopolysaccharide-induced NO production in murine microglial BV-2 cells of these terpenoids were evaluated, and all of the compounds showed inhibitory effects. The following molecular docking studies showed interactions of the bioactive compounds with the iNOS protein.
AB - A phytochemical investigation to obtain new NO inhibitors resulted in the isolation of a new diterpenoid with a rare 9,10-seco-abietane skeleton (1) and twelve known terpenoids (2–13) from Callicarpa kwangtungensis. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analyses, and the absolute configuration of compound 1 was established by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. The inhibitory activities on lipopolysaccharide-induced NO production in murine microglial BV-2 cells of these terpenoids were evaluated, and all of the compounds showed inhibitory effects. The following molecular docking studies showed interactions of the bioactive compounds with the iNOS protein.
KW - 9,10-seco-Abietane diterpenoid
KW - Callicarpa kwangtungensis
KW - Molecular docking
KW - NO inhibitory activities
KW - Terpenoids
KW - iNOS
UR - http://www.scopus.com/inward/record.url?scp=85007607517&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85007607517&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2016.11.044
DO - 10.1016/j.bmcl.2016.11.044
M3 - Article
C2 - 27989668
AN - SCOPUS:85007607517
SN - 0960-894X
VL - 27
SP - 670
EP - 674
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 3
ER -