Natural selection in a bangladeshi population from the cholera-endemic ganges river delta

Elinor K. Karlsson, Jason B. Harris, Shervin Tabrizi, Atiqur Rahman, Ilya Shlyakhter, Nick Patterson, Colm O'Dushlaine, Stephen F. Schaffner, Sameer Gupta, Fahima Chowdhury, Alaullah Sheikh, Ok Shin, Crystal Ellis, Christine E. Becker, Lynda M. Stuart, Stephen B. Calderwood, Edward T. Ryan, Firdausi Qadri, Pardis C. Sabeti, Regina C. LaRocque

Research output: Contribution to journalArticle

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Abstract

As an ancient disease with high fatality, cholera has likely exerted strong selective pressure on affected human populations. We performed a genome-wide study of natural selection in a population from the Ganges River Delta, the historic geographic epicenter of cholera. We identified 305 candidate selected regions using the composite of multiple signals (CMS) method. The regions were enriched for potassium channel genes involved in cyclic adenosine monophosphate-mediated chloride secretion and for components of the innate immune system involved in nuclear factor κB (NF-κB) signaling. We demonstrate that a number of these strongly selected genes are associated with cholera susceptibility in two separate cohorts. We further identify repeated examples of selection and association in an NF-κB/inflammasome-dependent pathway that is activated in vitro by Vibrio cholerae. Our findings shed light on the genetic basis of cholera resistance in a population from the Ganges River Delta and present a promising approach for identifying genetic factors influencing susceptibility to infectious diseases.

Original languageEnglish
Article number192ra86
JournalScience Translational Medicine
Volume5
Issue number192
DOIs
Publication statusPublished - 2013 Jul 3

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Cholera
Genetic Selection
Rivers
Population
Inflammasomes
Vibrio cholerae
Potassium Channels
Cyclic AMP
Genes
Communicable Diseases
Chlorides
Immune System
Genome

ASJC Scopus subject areas

  • Medicine(all)

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Karlsson, E. K., Harris, J. B., Tabrizi, S., Rahman, A., Shlyakhter, I., Patterson, N., ... LaRocque, R. C. (2013). Natural selection in a bangladeshi population from the cholera-endemic ganges river delta. Science Translational Medicine, 5(192), [192ra86]. https://doi.org/10.1126/scitranslmed.3006338

Natural selection in a bangladeshi population from the cholera-endemic ganges river delta. / Karlsson, Elinor K.; Harris, Jason B.; Tabrizi, Shervin; Rahman, Atiqur; Shlyakhter, Ilya; Patterson, Nick; O'Dushlaine, Colm; Schaffner, Stephen F.; Gupta, Sameer; Chowdhury, Fahima; Sheikh, Alaullah; Shin, Ok; Ellis, Crystal; Becker, Christine E.; Stuart, Lynda M.; Calderwood, Stephen B.; Ryan, Edward T.; Qadri, Firdausi; Sabeti, Pardis C.; LaRocque, Regina C.

In: Science Translational Medicine, Vol. 5, No. 192, 192ra86, 03.07.2013.

Research output: Contribution to journalArticle

Karlsson, EK, Harris, JB, Tabrizi, S, Rahman, A, Shlyakhter, I, Patterson, N, O'Dushlaine, C, Schaffner, SF, Gupta, S, Chowdhury, F, Sheikh, A, Shin, O, Ellis, C, Becker, CE, Stuart, LM, Calderwood, SB, Ryan, ET, Qadri, F, Sabeti, PC & LaRocque, RC 2013, 'Natural selection in a bangladeshi population from the cholera-endemic ganges river delta', Science Translational Medicine, vol. 5, no. 192, 192ra86. https://doi.org/10.1126/scitranslmed.3006338
Karlsson EK, Harris JB, Tabrizi S, Rahman A, Shlyakhter I, Patterson N et al. Natural selection in a bangladeshi population from the cholera-endemic ganges river delta. Science Translational Medicine. 2013 Jul 3;5(192). 192ra86. https://doi.org/10.1126/scitranslmed.3006338
Karlsson, Elinor K. ; Harris, Jason B. ; Tabrizi, Shervin ; Rahman, Atiqur ; Shlyakhter, Ilya ; Patterson, Nick ; O'Dushlaine, Colm ; Schaffner, Stephen F. ; Gupta, Sameer ; Chowdhury, Fahima ; Sheikh, Alaullah ; Shin, Ok ; Ellis, Crystal ; Becker, Christine E. ; Stuart, Lynda M. ; Calderwood, Stephen B. ; Ryan, Edward T. ; Qadri, Firdausi ; Sabeti, Pardis C. ; LaRocque, Regina C. / Natural selection in a bangladeshi population from the cholera-endemic ganges river delta. In: Science Translational Medicine. 2013 ; Vol. 5, No. 192.
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