Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores

Fabio de Moliner, Ina Biazruchka, Karolina Konsewicz, Sam Benson, Suraj Singh, Jun Seok Lee, Marc Vendrell

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The development of fluorophores emitting in the near-infrared spectral window has gained increased attention given their suitable features for biological imaging. In this work, we have optimised a general and straightforward synthetic approach to prepare a small library of near-infrared-emitting C-bridged nitrobenzodiazoles using commercial precursors. C-bridged benzodiazoles have low molecular weight and neutral character as important features that are not common in most near-infrared dyes. We have investigated their fluorescence response in the presence of a wide array of 60 different biomolecules and identified compound 3i as a potential chemosensor to discriminate between Fe2+ and Fe3+ ions in aqueous media. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)128-135
Number of pages8
JournalFrontiers of Chemical Science and Engineering
Issue number1
Publication statusPublished - 2022 Jan


  • fluorescence
  • iron
  • library
  • probes
  • screening

ASJC Scopus subject areas

  • Chemical Engineering(all)


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