Near-infrared fluorescent probes for the detection of glutathione and their application in the fluorescence imaging of living cells and tumor-bearing mice

Dayoung Lee, Keunsoo Jeong, Xiao Luo, Gayoung Kim, Youjun Yang, Xiaoqiang Chen, Sehoon Kim, Juyoung Yoon

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Two new cyanine-based fluorescent probes 1 and 2 have been developed. Probe 1 bears two cyanine units in a single molecule, and probe 2 contains a bis(trifluoromethyl)benzenethiol moiety. Both are non-fluorescent. The addition of intracellular glutathione (GSH) significantly enhanced the NIR fluorescence of the two probes. Both probes were used to image varying amounts of GSH in living cells. In tumor bearing mice, the in vivo fluorescence intensity of both probes was higher in tumors, where GSH is overexpressed, than in normal tissues. These results suggest that these new fluorogenic probes have potential for GSH-targeting diagnostic imaging.

Original languageEnglish
Pages (from-to)2541-2546
Number of pages6
JournalJournal of Materials Chemistry B
Volume6
Issue number17
DOIs
Publication statusPublished - 2018 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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