Abstract
Introduction Negative myoclonus is a jerky, brief, and sudden interruption of voluntary muscle contraction. Although gabapentin and pregabalin have been reported to induce positive myoclonus in some patients with impaired renal function, there are only a few studies describing pregabalin- or gabapentin-induced negative myoclonus. This study reviewed patients who had developed pregabalin- or gabapentin-induced negative myoclonus. Methods We collected the patients with negative myoclonus who were referred to the department of neurology at a university-affiliated hospital and selected pregabalin- or gabapentin-induced negative myoclonus. Then reviewed the literature with respect to pregabalin- or gabapentin-induced negative myoclonus. Results A total of 77 patients with negative myoclonus were reviewed. Among them, 21 neuropathic pain patients who were prescribed and developed negative myoclonus induced by pregabalin (9 cases) or gabapentin (12 cases). To prove causality of the drug, probable and certain level of category according to the WHO-UMC criteria were recruited. Of the 21 patients, 3 had impaired renal function, while 18 had normal renal function. Review of the literature identified 7 further cases (6 had normal renal function) with pregabalin- or gabapentin-induced negative myoclonus. Conclusion Pregabalin- and gabapentin-induced negative myoclonus can develop even in patients with normal renal function. Physicians should keep in mind the possibility of patients developing negative myoclonus under treatment of pregabalin or gabapentin even in short period of time and with low dosage, and in the normal range of renal function. Further prospective study investigating incidence and risk factors is warranted.
| Original language | English |
|---|---|
| Pages (from-to) | 36-39 |
| Number of pages | 4 |
| Journal | Journal of the Neurological Sciences |
| Volume | 382 |
| DOIs | |
| Publication status | Published - 2017 Nov 15 |
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Keywords
- Gabapentin
- Negative myoclonus
- Pregabalin
- Renal function
- T-type calcium channel
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Negative myoclonus induced by gabapentin and pregabalin : A case series and systematic literature review. / Kim, Jung Bin; Jung, Jin-Man; Park, Moon Ho; Lee, Eun Ju; Kwon, Do-Young.
In: Journal of the Neurological Sciences, Vol. 382, 15.11.2017, p. 36-39.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Negative myoclonus induced by gabapentin and pregabalin
T2 - A case series and systematic literature review
AU - Kim, Jung Bin
AU - Jung, Jin-Man
AU - Park, Moon Ho
AU - Lee, Eun Ju
AU - Kwon, Do-Young
PY - 2017/11/15
Y1 - 2017/11/15
N2 - Introduction Negative myoclonus is a jerky, brief, and sudden interruption of voluntary muscle contraction. Although gabapentin and pregabalin have been reported to induce positive myoclonus in some patients with impaired renal function, there are only a few studies describing pregabalin- or gabapentin-induced negative myoclonus. This study reviewed patients who had developed pregabalin- or gabapentin-induced negative myoclonus. Methods We collected the patients with negative myoclonus who were referred to the department of neurology at a university-affiliated hospital and selected pregabalin- or gabapentin-induced negative myoclonus. Then reviewed the literature with respect to pregabalin- or gabapentin-induced negative myoclonus. Results A total of 77 patients with negative myoclonus were reviewed. Among them, 21 neuropathic pain patients who were prescribed and developed negative myoclonus induced by pregabalin (9 cases) or gabapentin (12 cases). To prove causality of the drug, probable and certain level of category according to the WHO-UMC criteria were recruited. Of the 21 patients, 3 had impaired renal function, while 18 had normal renal function. Review of the literature identified 7 further cases (6 had normal renal function) with pregabalin- or gabapentin-induced negative myoclonus. Conclusion Pregabalin- and gabapentin-induced negative myoclonus can develop even in patients with normal renal function. Physicians should keep in mind the possibility of patients developing negative myoclonus under treatment of pregabalin or gabapentin even in short period of time and with low dosage, and in the normal range of renal function. Further prospective study investigating incidence and risk factors is warranted.
AB - Introduction Negative myoclonus is a jerky, brief, and sudden interruption of voluntary muscle contraction. Although gabapentin and pregabalin have been reported to induce positive myoclonus in some patients with impaired renal function, there are only a few studies describing pregabalin- or gabapentin-induced negative myoclonus. This study reviewed patients who had developed pregabalin- or gabapentin-induced negative myoclonus. Methods We collected the patients with negative myoclonus who were referred to the department of neurology at a university-affiliated hospital and selected pregabalin- or gabapentin-induced negative myoclonus. Then reviewed the literature with respect to pregabalin- or gabapentin-induced negative myoclonus. Results A total of 77 patients with negative myoclonus were reviewed. Among them, 21 neuropathic pain patients who were prescribed and developed negative myoclonus induced by pregabalin (9 cases) or gabapentin (12 cases). To prove causality of the drug, probable and certain level of category according to the WHO-UMC criteria were recruited. Of the 21 patients, 3 had impaired renal function, while 18 had normal renal function. Review of the literature identified 7 further cases (6 had normal renal function) with pregabalin- or gabapentin-induced negative myoclonus. Conclusion Pregabalin- and gabapentin-induced negative myoclonus can develop even in patients with normal renal function. Physicians should keep in mind the possibility of patients developing negative myoclonus under treatment of pregabalin or gabapentin even in short period of time and with low dosage, and in the normal range of renal function. Further prospective study investigating incidence and risk factors is warranted.
KW - Gabapentin
KW - Negative myoclonus
KW - Pregabalin
KW - Renal function
KW - T-type calcium channel
UR - http://www.scopus.com/inward/record.url?scp=85029683382&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029683382&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2017.09.019
DO - 10.1016/j.jns.2017.09.019
M3 - Article
C2 - 29111014
AN - SCOPUS:85029683382
VL - 382
SP - 36
EP - 39
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
ER -