Negative regulatory role of Annexin-A1 in 14-3-3η-mediated glucocorticoid receptor transcriptional activation

Ho Joong Sung, Yong Suk Ryang, Yoon Suk Kim, Sung Wuk Jang, Doe Sun Na, Jesang Ko

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Annexin-A1 (ANX-1) is involved in glucocorticoid receptor (GR)-mediated signal transduction. However, the molecular mechanism by which ANX-1 plays a role in GR signaling is not fully understood. Recently, we reported that 14-3-3η inhibits degradation of GR, resulting in an increase in GR transcriptional activity. In this study, we have addressed the role of ANX-1 in 14-3-3η-induced enhancement of GR transactivation. ANX-1 abolished the increase in GR transcriptional activity due to 14-3-3η. ANX-1 had no effect on the protein level of GR. However, ANX-1 abrogated the inhibitory effect of 14-3-3η on GR degradation, which causes a decrease in GR stability in the nucleus. Our results indicate that ANX-1 functions as a negative regulator of GR transcriptional activation by inhibiting 14-3-3η-induced up-regulation of GR.

Original languageEnglish
Pages (from-to)1208-1211
Number of pages4
JournalBiochemical and biophysical research communications
Volume339
Issue number4
DOIs
Publication statusPublished - 2006 Jan 27

Keywords

  • 14-3-3η
  • Annexin-A1
  • Dexamethasone
  • Glucocorticoid receptor
  • Inflammation
  • Transcriptional activation

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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