Neo-Clerodane Diterpenoids from Scutellaria barbata and Their Inhibitory Effects on LPS-Induced Nitric Oxide Production

Eung Tae Yeon, Jin Woo Lee, Chul Lee, Qinghao Jin, Hari Jang, Dongho Lee, Jong Seog Ahn, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang

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18 Citations (Scopus)

Abstract

Three new neo-clerodane diterpenoids (1-3) along with 12 known compounds (4-15) were isolated from a methanol extract of the aerial parts of Scutellaria barbata. The structures of 1-3 were determined by interpretation of their 1D and 2D NMR spectroscopic data as well as HRESIMS values. All isolated compounds were tested for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Compounds 1-4, 7, and 10-12 were found to inhibit nitric oxide production with IC50 values ranging from 20.2 to 35.6 M.

Original languageEnglish
Pages (from-to)2292-2296
Number of pages5
JournalJournal of Natural Products
Volume78
Issue number9
DOIs
Publication statusPublished - 2015 Sep 25

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Analytical Chemistry
  • Organic Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine

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  • Cite this

    Yeon, E. T., Lee, J. W., Lee, C., Jin, Q., Jang, H., Lee, D., Ahn, J. S., Hong, J. T., Kim, Y., Lee, M. K., & Hwang, B. Y. (2015). Neo-Clerodane Diterpenoids from Scutellaria barbata and Their Inhibitory Effects on LPS-Induced Nitric Oxide Production. Journal of Natural Products, 78(9), 2292-2296. https://doi.org/10.1021/acs.jnatprod.5b00126