Neonatal brain MRI segmentation by building multi-region-multi-reference atlases

Feng Shi, Pew Thian Yap, Yong Fan, John H. Gilmore, Weili Lin, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Neonatal brain MRI segmentation is challenging due to the poor image quality. Existing population atlases used for guiding segmentation are usually constructed by averaging all images in a population with no preference. However, such approaches diminish the important local inter-subject structural variability. In this paper, we propose a multiregion- multi-reference strategy for atlas building from a population. In brief, the brain is first parcellated into multiple anatomical regions, and for each region, the population images are classified into different subpopulations. The exemplars in sub-populations serve as structural references when determining the most suitable regional atlas for a to-be-segmented image. A final atlas is generated by combining all selected regional atlases, and a joint registration-segmentation strategy is employed for tissue segmentation. Experimental results demonstrate that segmentation with our atlas achieves high average tissue overlap rates with manual golden standard of 0.86 (SD 0.02) for gray matter (GM) and 0.83 (SD 0.03) for white matter (WM), and outperforms other atlases in comparison.

Original languageEnglish
Title of host publication2010 7th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI 2010 - Proceedings
Pages964-967
Number of pages4
DOIs
Publication statusPublished - 2010
Event7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Rotterdam, Netherlands
Duration: 2010 Apr 142010 Apr 17

Publication series

Name2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings

Other

Other7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010
CountryNetherlands
CityRotterdam
Period10/4/1410/4/17

Keywords

  • Joint registration-segmentation
  • Multiple atlases
  • Neonatal imaging
  • Tissue segmentation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Shi, F., Yap, P. T., Fan, Y., Gilmore, J. H., Lin, W., & Shen, D. (2010). Neonatal brain MRI segmentation by building multi-region-multi-reference atlases. In 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings (pp. 964-967). [5490148] (2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings). https://doi.org/10.1109/ISBI.2010.5490148