Nephroprotection of plantamajoside in rats treated with cadmium

Ha Young Jung; Dong Won Seo; Chung Oui Hong; Ji Yeon Kim; Sung Yong Yang; Kwang Won Lee

doi:10.1016/j.etap.2014.11.012

Nephroprotection of plantamajoside in rats treated with cadmium

Ha Young Jung, Dong Won Seo, Chung Oui Hong, Ji Yeon Kim, Sung Yong Yang, Kwang Won Lee

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Cadmium (Cd), an environmental and industrial pollutant, generates free radicals responsible for oxidative stress. Cd can also lead to various renal toxic damage such as the proximal tubules and glomerulus dysfunction. Plantamajoside (PMS), a major compound of Plantago asiatica (PA), was reported to have the antioxidant effects. In this study, we investigated the protective effects of PMS on Cd-induced renal damage in the NRK-52E cell and rat kidney tissue. Cd exposure increased the ROS generation, lipid peroxidation, serum biochemical values of renal damage, and mRNA and protein expressions of KIM-1 in vitro and in vivo. The significant reduction in glutathione (GSH)/glutathione disulfide (GSSG) ratio and activities of antioxidant enzymes were also observed in the rats treated with Cd. PMS significantly decreased the ROS generation and lipid peroxidation, thus enhancing GSH/GSSG ratio, antioxidant enzyme activities in the cells and rats, and improved histochemical appearances, indicating that PMS has protective activities against Cd-induced renal injury.

Original language	English
Pages (from-to)	125-136
Number of pages	12
Journal	Environmental Toxicology and Pharmacology
Volume	39
Issue number	1
DOIs	https://doi.org/10.1016/j.etap.2014.11.012
Publication status	Published - 2015 Jan 1

Keywords

Cadmium
Kidney injury molecule-1
Lipid peroxidation
Nephrotoxicity
Oxidative stress
Plantamajoside

ASJC Scopus subject areas

Toxicology
Pharmacology
Health, Toxicology and Mutagenesis

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title = "Nephroprotection of plantamajoside in rats treated with cadmium",

abstract = "Cadmium (Cd), an environmental and industrial pollutant, generates free radicals responsible for oxidative stress. Cd can also lead to various renal toxic damage such as the proximal tubules and glomerulus dysfunction. Plantamajoside (PMS), a major compound of Plantago asiatica (PA), was reported to have the antioxidant effects. In this study, we investigated the protective effects of PMS on Cd-induced renal damage in the NRK-52E cell and rat kidney tissue. Cd exposure increased the ROS generation, lipid peroxidation, serum biochemical values of renal damage, and mRNA and protein expressions of KIM-1 in vitro and in vivo. The significant reduction in glutathione (GSH)/glutathione disulfide (GSSG) ratio and activities of antioxidant enzymes were also observed in the rats treated with Cd. PMS significantly decreased the ROS generation and lipid peroxidation, thus enhancing GSH/GSSG ratio, antioxidant enzyme activities in the cells and rats, and improved histochemical appearances, indicating that PMS has protective activities against Cd-induced renal injury.",

keywords = "Cadmium, Kidney injury molecule-1, Lipid peroxidation, Nephrotoxicity, Oxidative stress, Plantamajoside",

author = "Jung, {Ha Young} and Seo, {Dong Won} and Hong, {Chung Oui} and Kim, {Ji Yeon} and Yang, {Sung Yong} and Lee, {Kwang Won}",

note = "Funding Information: This research was a part of the project (Grant No. R1111343 ) titled {\textquoteleft}Material development and commercialization of Korean seaweed alga ( Capsosiphon fulvescens ) conferring whitening function, anti-diabetes, and inhibitory effects on diabetic complications{\textquoteright}, funded by the Ministry of Oceans and Fisheries, Korea . Publisher Copyright: {\textcopyright} 2014 Elsevier B.V.",

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AU - Jung, Ha Young

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AU - Kim, Ji Yeon

AU - Yang, Sung Yong

AU - Lee, Kwang Won

N1 - Funding Information: This research was a part of the project (Grant No. R1111343 ) titled ‘Material development and commercialization of Korean seaweed alga ( Capsosiphon fulvescens ) conferring whitening function, anti-diabetes, and inhibitory effects on diabetic complications’, funded by the Ministry of Oceans and Fisheries, Korea . Publisher Copyright: © 2014 Elsevier B.V.

PY - 2015/1/1

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N2 - Cadmium (Cd), an environmental and industrial pollutant, generates free radicals responsible for oxidative stress. Cd can also lead to various renal toxic damage such as the proximal tubules and glomerulus dysfunction. Plantamajoside (PMS), a major compound of Plantago asiatica (PA), was reported to have the antioxidant effects. In this study, we investigated the protective effects of PMS on Cd-induced renal damage in the NRK-52E cell and rat kidney tissue. Cd exposure increased the ROS generation, lipid peroxidation, serum biochemical values of renal damage, and mRNA and protein expressions of KIM-1 in vitro and in vivo. The significant reduction in glutathione (GSH)/glutathione disulfide (GSSG) ratio and activities of antioxidant enzymes were also observed in the rats treated with Cd. PMS significantly decreased the ROS generation and lipid peroxidation, thus enhancing GSH/GSSG ratio, antioxidant enzyme activities in the cells and rats, and improved histochemical appearances, indicating that PMS has protective activities against Cd-induced renal injury.

AB - Cadmium (Cd), an environmental and industrial pollutant, generates free radicals responsible for oxidative stress. Cd can also lead to various renal toxic damage such as the proximal tubules and glomerulus dysfunction. Plantamajoside (PMS), a major compound of Plantago asiatica (PA), was reported to have the antioxidant effects. In this study, we investigated the protective effects of PMS on Cd-induced renal damage in the NRK-52E cell and rat kidney tissue. Cd exposure increased the ROS generation, lipid peroxidation, serum biochemical values of renal damage, and mRNA and protein expressions of KIM-1 in vitro and in vivo. The significant reduction in glutathione (GSH)/glutathione disulfide (GSSG) ratio and activities of antioxidant enzymes were also observed in the rats treated with Cd. PMS significantly decreased the ROS generation and lipid peroxidation, thus enhancing GSH/GSSG ratio, antioxidant enzyme activities in the cells and rats, and improved histochemical appearances, indicating that PMS has protective activities against Cd-induced renal injury.

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Nephroprotection of plantamajoside in rats treated with cadmium

Abstract

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