Nestin expression as an indicator of cervical cancer initiation

H. S. Bae, Y. W. Chung, Jae Kwan Lee, Nak Woo Lee, B. W. Yeom, K. W. Lee, Jae Yun Song

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Nestin is an intermediate filament protein expressed in proliferating cells during embryonic development of the central nervous system (CNS) and considered to be a neuronal stem cell/progenitor cell marker. This study investigated the difference of nestin expression between pre-cancer (carcinoma in situ - CIS) and cancer of cervix in 129 tissues (49 normal cervix, 41 CIS, and 39 invasive cervical cancer) through the use of a paraffin-embedded tissue array. Immunostaining was evaluated by intensity, proportion of stained cells, and pattern of expression. The expression of nestin was positive in 63.4% (26/41) for CIS and 43.6% (17/39) for invasive cervical cancer, but only 26.5% (13/49) for normal tissues (p = 0.002). Strong positive staining/large proportion staining were 53.7% (22/41) / 36.6% (15/41), 15.4% (6/39) / 61.5% (24/39) in the CIS and invasive cervical cancer tissues, respectively (p = 0.043, p < 0.001). The diffuse stain with basal layer was positive in 90.2% (37/41) for CIS, but only 24.5% (12/49) of the samples were positive in normal tissues (p < 0.001). Based on these results, the authors suggest that nestin expression seems to participate in the step of cancer initiation and could potentially be a useful marker in the early detection of cervical cancer.

Original languageEnglish
Pages (from-to)238-242
Number of pages5
JournalEuropean Journal of Gynaecological Oncology
Volume34
Issue number3
Publication statusPublished - 2013 Jul 5

Fingerprint

Nestin
Uterine Cervical Neoplasms
Stem Cells
Staining and Labeling
Intermediate Filament Proteins
Carcinoma in Situ
Early Detection of Cancer
Cervix Uteri
Paraffin
Embryonic Development
Neoplasms
Coloring Agents
Central Nervous System

Keywords

  • Cervical cancer
  • CIS
  • Nestin

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Nestin expression as an indicator of cervical cancer initiation. / Bae, H. S.; Chung, Y. W.; Lee, Jae Kwan; Lee, Nak Woo; Yeom, B. W.; Lee, K. W.; Song, Jae Yun.

In: European Journal of Gynaecological Oncology, Vol. 34, No. 3, 05.07.2013, p. 238-242.

Research output: Contribution to journalArticle

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