Network beyond IDO in psychiatric disorders: Revisiting neurodegeneration hypothesis

Aye Mu Myint, Yong Ku Kim

    Research output: Contribution to journalArticlepeer-review

    138 Citations (Scopus)

    Abstract

    The involvement of immune system activation in the pathophysiology of certain psychiatric disorders is well documented. Inflammatory molecules such as pro-inflammatory cytokines could enhance the activity of the indoleamine 2,3-dioxygenase (IDO) enzyme which is the first rate-limiting enzyme of the tryptophan degradation pathway, the kynurenine pathway. The increased tryptophan degradation could induce serotonin depletion and depressive mood. On the other hand, the downstream metabolites from this pathway, such as 3-hydroxykynurenine, quinolinic acid and kynurenic acid, are neuroactive metabolites which can modulate several neurotransmissions, such as glutamatergic, GABAergic, dopaminergic and noradrenergic neurotransmissions, which in turn induce changes in neuronal-glial network and neuropsychiatric consequences. In this issue, we have revised the previous 'neurodegeneration hypothesis,' which explained the involvement of cytokines and IDO pathway interaction in depression, with a further extended view related to the network beyond IDO, the network between immune molecules, tryptophan metabolites and different neurotransmitters, in depression and other major psychiatric disorders such as schizophrenia, bipolar disorder and childhood psychiatric disorders.

    Original languageEnglish
    Pages (from-to)304-313
    Number of pages10
    JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
    Volume48
    DOIs
    Publication statusPublished - 2014 Jan 3

    Keywords

    • Bipolar
    • Depression
    • Glutamate
    • IDO
    • Kynurenine
    • Schizophrenia

    ASJC Scopus subject areas

    • Pharmacology
    • Biological Psychiatry

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