Neural Organoids, a Versatile Model for Neuroscience

Ju Hyun Lee, Woong Sun

Research output: Contribution to journalShort surveypeer-review

1 Citation (Scopus)

Abstract

Three-dimensional cultures of human neural tissue/organlike structures in vitro can be achieved by mimicking the developmental processes occurring in vivo. Rapid progress in the field of neural organoids has fueled the hope (and hype) for improved understanding of brain development and functions, modeling of neural diseases, discovery of new drugs, and supply of surrogate sources of transplantation. In this short review, we summarize the state-of-the-art applications of this fascinating tool in various research fields and discuss the reality of the technique hoping that the current limitations will soon be overcome by the efforts of ingenious researchers.

Original languageEnglish
Pages (from-to)53-64
Number of pages12
JournalMolecules and cells
Volume45
Issue number2
DOIs
Publication statusPublished - 2022 Feb 28

Keywords

  • central nervous system
  • human pluripotent stem cells
  • in vitro modeling
  • neurodevelopment
  • neurological disorders
  • organoid

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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