Neural substrate in a case of foreign accent syndrome following basal ganglia hemorrhage

Sung Bom Pyun, Seung gul Jang, Seonghee Lim, Ji Wan Ha, Hyesook Cho

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Foreign accent syndrome (FAS) is a rare expressive language output disorder due to acquired inability to make the normal phonetic and phonemic contrasts of one's native dialect. A 37-year-old woman who was monolingual in Korean developed FAS after a left basal ganglia hemorrhage. We assessed perceived speech by phonetic analysis and diffusion tensor tractography (DTT) and performed functional magnetic resonance imaging (fMRI) using a picture naming task. One year after the onset of FAS, her initial English-like accent substantially improved to a Seoul accent, but was not completely recovered to the prestroke level. DTT showed disconnected and decreased numbers of fibers in the left arcuate fasciculus (AF), and these findings were unchanged when the patient was assessed at follow-up. The fMRI analysis showed activation on the bilateral cortical and subcortical speech-motor network: 1) the left cortical language area including Broca's area, the oromotor cortex, and the bilateral superior cerebellum, and 2) the right subcortical structures, including the caudate and thalamus. Our findings suggest that FAS may be caused by the disruption of the cortico-subcortical language network and that subcortical structures, including the basal ganglia, may have an important role in the development of speech motor control deficits in FAS. We also found that neuroplastic change in the damaged cortico-subcortical speech-motor network compensates for FAS and induces clinical improvement.

Original languageEnglish
Pages (from-to)479-489
Number of pages11
JournalJournal of Neurolinguistics
Volume26
Issue number4
DOIs
Publication statusPublished - 2013 Jul 1

Fingerprint

Basal Ganglia Hemorrhage
Sodium Glutamate
phonetics
language
Phonetics
Diffusion Tensor Imaging
dialect
activation
deficit
Language
Magnetic Resonance Imaging
Language Disorders
Activation Analysis
Basal Ganglia
Substrate
Foreign Accent Syndrome
Thalamus
Cerebellum

Keywords

  • Aphasia
  • Apraxia of speech
  • Basal ganglia
  • Foreign accent syndrome
  • Functional MRI

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Arts and Humanities (miscellaneous)
  • Linguistics and Language
  • Cognitive Neuroscience

Cite this

Neural substrate in a case of foreign accent syndrome following basal ganglia hemorrhage. / Pyun, Sung Bom; Jang, Seung gul; Lim, Seonghee; Ha, Ji Wan; Cho, Hyesook.

In: Journal of Neurolinguistics, Vol. 26, No. 4, 01.07.2013, p. 479-489.

Research output: Contribution to journalArticle

Pyun, Sung Bom ; Jang, Seung gul ; Lim, Seonghee ; Ha, Ji Wan ; Cho, Hyesook. / Neural substrate in a case of foreign accent syndrome following basal ganglia hemorrhage. In: Journal of Neurolinguistics. 2013 ; Vol. 26, No. 4. pp. 479-489.
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