Neural substrates of affective face recognition in alexithymia: A functional magnetic resonance imaging study

Byeong Taek Lee, Hwa Young Lee, Sae Ah Park, Jin Young Lim, Woo Suk Tae, Min-Soo Lee, Sook Haeng Joe, In Kwa Jung, Byung-Joo Ham

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Alexithymia is a condition characterized by deficits in cognitive processing and the regulation of emotions. Several theories have been proposed for the underlying neurobiology, but the etiology of alexithymia remains unclear. Methods: Using functional magnetic resonance imaging, we investigated brain activation measured on the scale of alexithymia in 38 individuals who were presented with neutral, sad, or angry affective facial stimuli. Results: We found significant inverse correlations between the degree of alexithymia represented by the Korean version of the Toronto Alexithymia Scale (TAS-20K) and the intensity of the neural response to angry facial stimuli over neutral facial stimuli in the right caudate. This result was mainly due to the activations in factor 2 (difficulty describing feelings) in TAS-20K scale. Conclusions: The results suggest that functional impairments in the caudate of the fronto-striatal circuitry may play important roles in the pathophysiology of alexithymia.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalNeuropsychobiology
Volume63
Issue number2
DOIs
Publication statusPublished - 2011 Jan 1

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Affective Symptoms
Magnetic Resonance Imaging
Emotions
Corpus Striatum
Neurobiology
Facial Recognition
Brain

Keywords

  • Alexithymia
  • Facial stimuli
  • Functional magnetic resonance imaging

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuropsychology and Physiological Psychology
  • Biological Psychiatry

Cite this

Neural substrates of affective face recognition in alexithymia : A functional magnetic resonance imaging study. / Lee, Byeong Taek; Lee, Hwa Young; Park, Sae Ah; Lim, Jin Young; Tae, Woo Suk; Lee, Min-Soo; Joe, Sook Haeng; Jung, In Kwa; Ham, Byung-Joo.

In: Neuropsychobiology, Vol. 63, No. 2, 01.01.2011, p. 119-124.

Research output: Contribution to journalArticle

Lee, BT, Lee, HY, Park, SA, Lim, JY, Tae, WS, Lee, M-S, Joe, SH, Jung, IK & Ham, B-J 2011, 'Neural substrates of affective face recognition in alexithymia: A functional magnetic resonance imaging study', Neuropsychobiology, vol. 63, no. 2, pp. 119-124. https://doi.org/10.1159/000318086
Lee, Byeong Taek ; Lee, Hwa Young ; Park, Sae Ah ; Lim, Jin Young ; Tae, Woo Suk ; Lee, Min-Soo ; Joe, Sook Haeng ; Jung, In Kwa ; Ham, Byung-Joo. / Neural substrates of affective face recognition in alexithymia : A functional magnetic resonance imaging study. In: Neuropsychobiology. 2011 ; Vol. 63, No. 2. pp. 119-124.
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