Neuregulin-1 accelerates corneal epithelial wound healing

Won Yong Jeong, Hye Young Yoo, Chan Wha Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Corneal epithelial cells (CECs) play an important role in the function of the cornea, and are maintained by corneal epithelial stem cells (CESCs). Recent studies have shown that neuronal growth factors affect the proliferation and migration of CESCs. Neuregulin-1 (NR-1) is a neuronal growth factor that is expressed in the early stages of brain development. The aim of this study was to determine whether NR-1 activates corneal wound healing. We observed that NR-1 activated both proliferation and migration of CECs. In addition, the colony-forming efficacy of CESCs was enhanced. In mice, NR-1 treatment improved corneal wound healing. Furthermore, the expression of markers of corneal epithelium maintenance (ΔNp63) and CESC proliferation (Bmi-1 and Abcg2) was increased. These effects were mediated by intracellular signalling pathways (Stat3, Erk1/2 and p38). Taken together, our results suggest that NR-1 accelerates the recovery of corneal wounds, and may represent a novel treatment for corneal damage.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalGrowth Factors
DOIs
Publication statusAccepted/In press - 2018 Feb 15

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Keywords

  • cell migration
  • corneal cell
  • Neuregulin-1
  • proliferation
  • wound healing

ASJC Scopus subject areas

  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

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